1808714-73-9-EN6 EN6

EN6

For research use only. Not for therapeutic Use.

  • CAT Number: I018058
  • CAS Number: 1808714-73-9
  • Molecular Formula: C₁₉H₁₄F₂N₄O₂
  • Molecular Weight: 368.34
  • Purity: ≥95%
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EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase). EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, in a lysosome-dependent manner[1].


Catalog Number I018058
CAS Number 1808714-73-9
Molecular Formula C₁₉H₁₄F₂N₄O₂
Purity ≥95%
Target Autophagy
Reference

[1]. Chung CY, et al. Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition. Nat Chem Biol. 2019 Aug;15(8):776-785.

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