endo-BCN-O-PNB

• CAT Number: I015330
• CAS Number: 1263166-91-1
• Molecular Formula: C₁₇H₁₇NO₅
• Molecular Weight: 315.32
• Purity: ≥95%
• Target: PROTAC Linkers
• IUPAC Name: [(1S,8R)-9-bicyclo[6.1.0]non-4-ynyl]methyl (4-nitrophenyl) carbonate
• InChI: InChI=1S/C17H17NO5/c19-17(23-13-9-7-12(8-10-13)18(20)21)22-11-16-14-5-3-1-2-4-6-15(14)16/h7-10,14-16H,3-6,11H2/t14-,15+,16?
• InChIKey: QXNXOXMDBLHIDB-XYPWUTKMSA-N
• SMILES: C1C[C@@H]2[C@@H](C2COC(=O)OC3=CC=C(C=C3)[N+](=O)[O-])CCC#C1

Endo-BCN-O-PNB（Cat No.:I015330）is a bioorthogonal chemical compound used in click chemistry, particularly in the context of bioconjugation and drug delivery systems. It contains a bicyclononynyl (BCN) group, which can undergo a highly selective reaction with azides, making it useful for precise labeling and targeting in biological systems. The PNB (para-nitrobenzyl) moiety provides photolability, allowing controlled release of a conjugated molecule upon exposure to light. Endo-BCN-O-PNB is employed in molecular imaging, targeted therapy, and other applications requiring controlled, site-specific chemical reactions in complex biological environments.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.