Endothelial lipase inhibitor-1

• CAT Number: I019336
• CAS Number: 1466427-02-0
• Molecular Formula: C22H22N4O4
• Molecular Weight: 406.43
• Purity: ≥95%
• Synonyms: 5-amino-2,4-dioxo-N-[(1R)-5-phenylmethoxy-1,2,3,4-tetrahydronaphthalen-1-yl]-1H-pyrimidine-6-carboxamide
• InChI: InChI=1S/C22H22N4O4/c23-18-19(25-22(29)26-20(18)27)21(28)24-16-10-4-9-15-14(16)8-5-11-17(15)30-12-13-6-2-1-3-7-13/h1-3,5-8,11,16H,4,9-10,12,23H2,(H,24,28)(H2,25,26,27,29)/t16-/m1/s1
• InChIKey: DZBXQBHHXZDUJS-MRXNPFEDSA-N
• SMILES: C1CC(C2=C(C1)C(=CC=C2)OCC3=CC=CC=C3)NC(=O)C4=C(C(=O)NC(=O)N4)N

Endothelial lipase inhibitor-1 is a potent endothelial lipase inhibitor with an IC50 of 49 nM.

Reference

[1]. Hu CH, et al. Discovery and synthesis of tetrahydropyrimidinedione-4-carboxamides as endothelial lipase inhibitors. Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3721-3725.
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