Endotoxin inhibitor TFA

• CAT Number: I042047
• Molecular Formula: C67H103F18N15O24S2
• Molecular Weight: 1908.72
• Purity: ≥95%

Endotoxin inhibitor TFA is a synthetic peptide that binds lipid A with high affinity, thereby detoxifying LPS (HY-D1056) and preventing LPS-induced cytokine release in vivo. Endotoxin inhibitor TFA inhibits the febrile response to LPS with very low toxicity and lethality[1].
Endotoxin inhibitor (i.p.; 0.5 mg/kg) TFA significantly attenuates heat exposure-induced increases in mRNA for IL-1β, COX-2, IκB-β, and LPS activity, as well as heat exposure-induced hypothermia and plasma ACTH and catecholamine responses in aged rats[1].

Reference

[1]. Toshihiko Katafuchi, et al. Endotoxin inhibitor blocks heat exposure-induced expression of brain cytokine mRNA in aged rats. Brain Res Mol Brain Res. 2003 Oct 21;118(1-2):24-32.
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