Endoxifen E-isomer

• CAT Number: I000552
• CAS Number: 114828-90-9
• Molecular Formula: C25H27NO2
• Molecular Weight: 373.49
• Purity: ≥95%
• Target: Estrogen Receptor/ERR
• Solubility: DMSO: ≥ 32 mg/mL
• Storage: Store at -20°C
• IUPAC Name: 4-[(E)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol
• InChI: InChI=1S/C25H27NO2/c1-3-24(19-7-5-4-6-8-19)25(20-9-13-22(27)14-10-20)21-11-15-23(16-12-21)28-18-17-26-2/h4-16,26-27H,3,17-18H2,1-2H3/b25-24+
• InChIKey: MHJBZVSGOZTKRH-OCOZRVBESA-N
• SMILES: CC/C(=C(/C1=CC=C(C=C1)O)C2=CC=C(C=C2)OCCNC)/C3=CC=CC=C3

Endoxifen E-isomer (Cat.No:I000552) is a metabolite of tamoxifen and exhibits potent antiestrogenic activity. It acts by binding to estrogen receptors and inhibiting their activation, making it valuable in the treatment of hormone receptor-positive breast cancer. Endoxifen E-isomer offers a potential therapeutic option for patients resistant to tamoxifen therapy.

Reference

[1]. Elkins P, et al. Characterization of the isomeric configuration and impurities of (Z)-Endoxifen by 2D NMR, high resolution LC-MS, and quantitative HPLC analysis. J Pharm Biomed Anal. 2014 Jan;88:174-9.