Endoxifen hydrochloride

• CAT Number: I000720
• CAS Number: 1197194-41-4
• Molecular Formula: C25H28ClNO2
• Molecular Weight: 409.95
• Purity: ≥95%
• Target: Estrogen receptor
• Solubility: DMSO: ≥ 35 mg/mL
• Storage: Store at -20°C
• IUPAC Name: 4-[(Z)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol;hydrochloride
• InChI: InChI=1S/C25H27NO2.ClH/c1-3-24(19-7-5-4-6-8-19)25(20-9-13-22(27)14-10-20)21-11-15-23(16-12-21)28-18-17-26-2;/h4-16,26-27H,3,17-18H2,1-2H3;1H/b25-24-
• InChIKey: RPFIMPDXTABYCN-BJFQDICYSA-N
• SMILES: CCC(=C(C1=CC=C(C=C1)O)C2=CC=C(C=C2)OCCNC)C3=CC=CC=C3.Cl

Endoxifen hydrochloride（Cat No.:I000720） is the active metabolite of Tamoxifen, a well-known selective estrogen receptor modulator (SERM). As a potent antiestrogen, Endoxifen hydrochloride specifically targets the estrogen receptor, inhibiting its activity and blocking the effects of estrogen in estrogen-sensitive tissues. It is commonly used in the treatment of hormone receptor-positive breast cancer. Endoxifen hydrochloride’s ability to interfere with estrogen receptor signaling makes it an important therapeutic agent in the management of hormone-dependent cancers.

Reference

[1]. Wu X, et al. The tamoxifen metabolite, Endoxifen, is a potent antiestrogen that targets estrogen receptor alpha fordegradation in breast cancer cells. Cancer Res. 2009 Mar 1;69(5):1722-7.
[2]. Benedykcinska A, et al.Generation of brain tumours in mice by Cre-mediated recombination of neural progenitors in situ with the tamoxifen metabolite Endoxifen. Dis Model Mech. 2016 Feb;9(2):211-20.