For research use only. Not for therapeutic Use.
ENIPORIDE is a bioactive chemical.
| Catalog Number | M032654 |
| CAS Number | 176644-21-6 |
| Synonyms | N-(aminoiminomethyl)-2-methyl-5-(methylsulfonyl)-4-(1H-pyrrol-1-yl)-benzamide |
| Molecular Formula | C14H16N4O3S |
| Purity | ≥95% |
| Target | sodium-hydrogen exchanger |
| Solubility | Soluble in DMSO |
| Storage | Store at -20°C |
| IUPAC Name | N-(diaminomethylidene)-2-methyl-5-methylsulfonyl-4-pyrrol-1-ylbenzamide |
| InChI | InChI=1S/C14H16N4O3S/c1-9-7-11(18-5-3-4-6-18)12(22(2,20)21)8-10(9)13(19)17-14(15)16/h3-8H,1-2H3,(H4,15,16,17,19) |
| InChIKey | UADMBZFZZOBWBB-UHFFFAOYSA-N |
| SMILES | CC1=CC(=C(C=C1C(=O)N=C(N)N)S(=O)(=O)C)N2C=CC=C2 |
| Reference | </br>1:Population pharmacokinetics of eniporide and its metabolite in healthy subjects and patients with acute myocardial infarction. Bhattaram VA, Nagaraja NV, Peters T, Machnig T, Kroesser S, Kovar A, Derendorf H.J Clin Pharmacol. 2005 Jun;45(6):631-9. PMID: 15901744 </br>2:Effect of the Na+/H+ exchange inhibitor eniporide on cardiac performance and myocardial high energy phosphates in pigs subjected to cardioplegic arrest. Klass O, Fischer UM, Perez E, Easo J, Bosse M, Fischer JH, Tossios P, Mehlhorn U.Ann Thorac Surg. 2004 Feb;77(2):658-63. PMID: 14759455 </br>3:Na+ overload during ischemia and reperfusion in rat hearts: comparison of the Na+/H+ exchange blockers EIPA, cariporide and eniporide. ten Hove M, van Emous JG, van Echteld CJ.Mol Cell Biochem. 2003 Aug;250(1-2):47-54. PMID: 12962142 </br>4:The Na(+)/H(+) exchange inhibitor eniporide as an adjunct to early reperfusion therapy for acute myocardial infarction. Results of the evaluation of the safety and cardioprotective effects of eniporide in acute myocardial infarction (ESCAMI) trial. Zeymer U, Suryapranata H, Monassier JP, Opolski G, Davies J, Rasmanis G, Linssen G, Tebbe U, Schröder R, Tiemann R, Machnig T, Neuhaus KL; ESCAMI Investigators..J Am Coll Cardiol. 2001 Nov 15;38(6):1644-50. PMID: 11704395 Free Article</br>5:Pharmacokinetic/pharmacodynamic evaluation of the NHE inhibitor eniporide. Kovar A, Peters T, Beier N, Derendorf H.J Clin Pharmacol. 2001 Feb;41(2):139-48. Erratum in: J Clin Pharmacol 2001 May;41(5):585. PMID: 11210393 |
