For research use only. Not for therapeutic Use.
<p>Enniatin B1 has been shown to induce apoptosis in several cancer lines and to decrease the activation of the cell proliferation kinase, ERK (p44/p42).Enniatin B1also is being used in research on drug resistance mechanisms.</p>
| Catalog Number | R025532 |
| CAS Number | 19914-20-6 |
| Synonyms | 1,7,13-Trioxa-4,10,16-triazacyclooctadecane, cyclic peptide deriv.;?Cyclo(3-methyl-D-2-hydroxybutanoyl-N-methyl-L-isoleucyl-3-methyl-D-2-hydroxybutanoyl-N-methyl-L-valyl-3-methyl-D-2-hydroxybutanoyl-N-methyl-L-valyl); |
| Molecular Formula | C34H59N3O9 |
| Purity | ≥95% |
| Target | Stem Cell/Wnt |
| Storage | -20°C |
| InChIKey | UQCSETXJXJTMKO-UMURLBKASA-N |
| Reference | Ionophore antibiotics produced by the fungus Fusarium orthoceras var. enniatum and other Fusaria. Gaumann E. et al. , Experientia 1947, 3, 202.<br/><br/>/Sandwich/ complexation in cyclopeptides and its implications in membrane processes. Ivanov V.T. Ann. N. Y. Acad. Sci. 1975, 264, 221.<br/><br/>Interaction of cyclic peptides and depsipeptides with calmodulin. Mereish K.A. et al. , Pept. Res. 1990, 3, 233.<br/><br/>Enniatin has a new function as an inhibitor of Pdr5p, one of the ABC transporters in Saccharomyces cerevisiae. Hiraga K. et al. , Biochem. Biophys. Res. Commun. 2005, 328, 1119.<br/><br/>Enniatin exerts p53-dependent cytostatic and p53-independent cytotoxic activities against human cancer cells. Dornetshuber R. et al. , Chem. Res. Toxicol. 2007, 20, 465.</span></p> |
