Enpp-1-IN-19

For research use only. Not for therapeutic Use.

  • CAT Number: I040576
  • CAS Number: 2738583-25-8
  • Molecular Formula: C16H16N4O3S
  • Molecular Weight: 344.39
  • Purity: ≥95%
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Enpp-1-IN-19 (compound 29f) is an orally active ENPP1 inhibitor that inhibits cGAMP hydrolysis by ENPP1 (IC50=68 nM). Enpp-1-IN-19 increases anti-PD-L1 responses and inhibits tumor growth in CT26 syngeneic models. Enpp-1-IN-19 also enhances STING-mediated type I interferon responses, induces immune memory, and prevents tumor recurrence[1].


Catalog Number I040576
CAS Number 2738583-25-8
Synonyms

2-methyl-1-oxo-4-[[4-(sulfamoylamino)phenyl]methyl]phthalazine

Molecular Formula C16H16N4O3S
Purity ≥95%
InChI InChI=1S/C16H16N4O3S/c1-20-16(21)14-5-3-2-4-13(14)15(18-20)10-11-6-8-12(9-7-11)19-24(17,22)23/h2-9,19H,10H2,1H3,(H2,17,22,23)
InChIKey ZBMUKGSKMVACJQ-UHFFFAOYSA-N
SMILES CN1C(=O)C2=CC=CC=C2C(=N1)CC3=CC=C(C=C3)NS(=O)(=O)N
Reference

[1]. Cho Y et al. Discovery of Orally Bioavailable Phthalazinone Analogues as an ENPP1 Inhibitor for STING-Mediated Cancer Immunotherapy. J Med Chem. 2023 Nov 23;66(22):15141-15170.
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