Enpp-1-IN-2

• CAT Number: I043459
• CAS Number: 2378640-92-5
• Molecular Formula: C15H18N6
• Molecular Weight: 282.34
• Purity: ≥95%
• Synonyms: 6-[(3-aminophenyl)methyl]-N,N,5-trimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
• InChI: InChI=1S/C15H18N6/c1-10-13(8-11-5-4-6-12(16)7-11)14(20(2)3)21-15(19-10)17-9-18-21/h4-7,9H,8,16H2,1-3H3
• InChIKey: VUDSCOCEYOZLJD-UHFFFAOYSA-N
• SMILES: CC1=NC2=NC=NN2C(=C1CC3=CC(=CC=C3)N)N(C)C

Enpp-1-IN-2 (Compound C) is a potent ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1) inhibitor with IC50 values of 0.26, 0.48 and 2.0 μM evaluated by means of TG-mAMP, pNP-TMP, and ATP assays, respectively. TG (Tokyo Green)-mAMP: a newly synthesized sensitive ENPP1 fluorescence probe[1].

Reference

[1]. Kawaguchi M, et al. Development of an ENPP1 Fluorescence Probe for Inhibitor Screening, Cellular Imaging, and Prognostic Assessment of Malignant Breast Cancer. J Med Chem. 2019 Oct 24;62(20):9254-9269.
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