EP2 receptor antagonist-1

• CAT Number: I045076
• CAS Number: 848920-08-1
• Molecular Formula: C24H22N4O5
• Molecular Weight: 446.46
• Purity: ≥95%
• Synonyms: oxolan-2-ylmethyl 2-amino-1-(2,3-dihydro-1,4-benzodioxin-6-yl)pyrrolo[3,2-b]quinoxaline-3-carboxylate
• InChI: InChI=1S/C24H22N4O5/c25-22-20(24(29)33-13-15-4-3-9-30-15)21-23(27-17-6-2-1-5-16(17)26-21)28(22)14-7-8-18-19(12-14)32-11-10-31-18/h1-2,5-8,12,15H,3-4,9-11,13,25H2
• InChIKey: OHXALKVNKANGKL-UHFFFAOYSA-N
• SMILES: C1CC(OC1)COC(=O)C2=C(N(C3=NC4=CC=CC=C4N=C23)C5=CC6=C(C=C5)OCCO6)N

EP2 receptor antagonist-1 (compound 1) is a potent, reversible, and agonist dependent allosteric prostaglandin EP2 receptor antagonist. EP2 receptor antagonist-1 shows anti-inflammatory effects[1].

Reference

[1]. Jiang C, et, al. An Agonist Dependent Allosteric Antagonist of Prostaglandin EP2 Receptors. ACS Chem Neurosci. 2020 May 20;11(10):1436-1446.
 [Content Brief]