For research use only. Not for therapeutic Use.
EP2 receptor antagonist-2 (CID891729) is an antagonist of EP2 receptor. EP2 receptor antagonist-2 inhibits the EP2 receptor activation induced by PGE2. EP2 receptor antagonist-2 also suppresses lactate dehydrogenase (LDH) release induced by N-methyl-D-aspartate (NMDA)[1].
EP2 receptor antagonist-2 shows cytotoxicity against C6G cells with an CC50 value of 575 μM[1].
EP2 receptor antagonist-2 (20 μM; 30 min) decreases NMDA (30 µM)-induced LDH release in rat primary hippocampal neurons (DIV14)[1].
| Catalog Number | I041696 |
| CAS Number | 615273-95-5 |
| Synonyms | 4-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-yl]morpholine |
| Molecular Formula | C15H14F3N3O |
| Purity | ≥95% |
| InChI | InChI=1S/C15H14F3N3O/c16-15(17,18)13-10-12(11-4-2-1-3-5-11)19-14(20-13)21-6-8-22-9-7-21/h1-5,10H,6-9H2 |
| InChIKey | GCCXGRJKBSVDIZ-UHFFFAOYSA-N |
| SMILES | C1COCCN1C2=NC(=CC(=N2)C(F)(F)F)C3=CC=CC=C3 |
| Reference | [1]. Jiang J, et al. Discovery of 2-Piperidinyl Phenyl Benzamides and Trisubstituted Pyrimidines as Positive Allosteric Modulators of the Prostaglandin Receptor EP2. ACS Chem Neurosci. 2018 Apr 18;9(4):699-707. |
