For research use only. Not for therapeutic Use.
EphB1-IN-1 (Compound 1) is a potent EphB1 inhibitor with IC50s of 3.0, 15 and 220 nM against EphB1G703C, EphB1T697G and EphB1WT, respectively[1].
EphB1-IN-1 (Compound 1) and 3MB-PP1 (HY-102069) cause orthogonal inhibition of two Eph kinases in the same cell[1].
| Catalog Number | I042034 |
| CAS Number | 1980036-18-7 |
| Synonyms | 2-chloro-N-[4-(2-chloro-5-hydroxyanilino)quinazolin-7-yl]acetamide |
| Molecular Formula | C16H12Cl2N4O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C16H12Cl2N4O2/c17-7-15(24)21-9-1-3-11-13(5-9)19-8-20-16(11)22-14-6-10(23)2-4-12(14)18/h1-6,8,23H,7H2,(H,21,24)(H,19,20,22) |
| InChIKey | GVQPPCNXPVHIRJ-UHFFFAOYSA-N |
| SMILES | C1=CC2=C(C=C1NC(=O)CCl)N=CN=C2NC3=C(C=CC(=C3)O)Cl |
| Reference | [1]. Kung A, et al. A Chemical-Genetic Approach to Generate Selective Covalent Inhibitors of Protein Kinases. ACS Chem Biol. 2017 Jun 16;12(6):1499-1503. |
