Epibatidine 2HCl

• CAT Number: I026921
• CAS Number: 166374-43-2
• Molecular Formula: C11H15Cl3N2
• Molecular Weight: 281.6
• Purity: 98%
• Synonyms: Epibatidine Dihydrochloride; Epibatidine 2HCl; Epibatidine HCl
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 2-(6-chloropyridin-3-yl)-7-azabicyclo[2.2.1]heptane dihydrochloride
• InChI: InChI=1S/C11H13ClN2.2ClH/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8;;/h1,4,6,8-10,14H,2-3,5H2;2*1H
• InChIKey: DGNNWUINALNROG-UHFFFAOYSA-N
• SMILES: ClC1=CC=C(C2C(N3)CCC3C2)C=N1.[H]Cl.[H]Cl

Epibatidine 2HCl is a potent nicotinic agonist.

Reference

1: Quik M, Sum JD, Whiteaker P, McCallum SE, Marks MJ, Musachio J, McIntosh JM, Collins AC, Grady SR. Differential declines in striatal nicotinic receptor subtype function after nigrostriatal damage in mice. Mol Pharmacol. 2003 May;63(5):1169-79. PubMed PMID: 12695545.
2: Kulak JM, McIntosh JM, Quik M. Loss of nicotinic receptors in monkey striatum after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment is due to a decline in alpha-conotoxin MII sites. Mol Pharmacol. 2002 Jan;61(1):230-8. PubMed PMID: 11752225.