For research use only. Not for therapeutic Use.
Epiblastin A is an ATP competitive casein kinase 1 (CK1) inhibitor with IC50s of 8.9, 0.5, and 4.7 µM for CK1α, CK1δ, and CK1 ɛ, respectively. Epiblastin A induces reprogramming of epiblast stem cells into embryonic stem cells by inhibition of CK1[1].
| Catalog Number | I011898 |
| CAS Number | 16470-02-3 |
| Synonyms | 6-(3-chlorophenyl)pteridine-2,4,7-triamine |
| Molecular Formula | C12H10ClN7 |
| Purity | ≥95% |
| InChI | InChI=1S/C12H10ClN7/c13-6-3-1-2-5(4-6)7-9(14)18-11-8(17-7)10(15)19-12(16)20-11/h1-4H,(H6,14,15,16,18,19,20) |
| InChIKey | ZWNKKZSRANLVEW-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC(=C1)Cl)C2=NC3=C(N=C(N=C3N=C2N)N)N |
| Reference | [1]. Andrei Ursu, et al. Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1. Cell Chem Biol. 2016 Apr 21;23(4):494-507. |
