Epinastine

• CAT Number: I004917
• CAS Number: 80012-43-7
• Molecular Formula: C16H15N3
• Molecular Weight: 249.31
• Purity: ≥95%
• Target: Neuronal Signaling
• Solubility: DMSO 57 mg/mL; Water 57 mg/mL
• Storage: Store at RT
• IUPAC Name: 2,4-diazatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),3,7,9,11,14,16-heptaen-3-amine
• InChI: InChI=1S/C16H15N3/c17-16-18-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)19(15)16/h1-8,15H,9-10H2,(H2,17,18)
• InChIKey: WHWZLSFABNNENI-UHFFFAOYSA-N
• SMILES: C1C2C3=CC=CC=C3CC4=CC=CC=C4N2C(=N1)N

Epinastine（Cat No.:I004917）, also known as WAL801, is a multifunctional pharmaceutical compound with antihistamine and mast cell stabilizing properties. As an effective and selective histamine H1 receptor antagonist, it helps alleviate allergy symptoms by blocking histamine’s effects. Additionally, Epinastine inhibits the release of interleukin-8 (IL-8), a pro-inflammatory cytokine, contributing to its anti-allergic and anti-inflammatory effects. This makes it valuable for managing various allergic conditions. Epinastine can be administered orally, allowing for convenient and systemic treatment, making it a versatile tool in combating allergies and associated inflammatory responses.

Reference

[1]. Fugner, A., et al., In vitro and in vivo studies of the non-sedating antihistamine epinastine. Arzneimittelforschung, 1988. 38(10): p. 1446-53.

[2]. Roeder, T., J. Degen, and M. Gewecke, Epinastine, a highly specific antagonist of insect neuronal octopamine receptors. Eur J Pharmacol, 1998. 349(2-3): p. 171-7.

[3]. Kamei, C., et al., Antiallergic effect of epinastine (WAL 801 CL) on immediate hypersensitivity reactions: (I). Elucidation of the mechanism for histamine release inhibition. Immunopharmacol Immunotoxicol, 1992. 14(1-2): p. 191-205.

[4]. Kohyama, T., et al., A novel antiallergic drug epinastine inhibits IL-8 release from human eosinophils. Biochem Biophys Res Commun, 1997. 230(1): p. 125-8.