Epitalon acetate

• CAT Number: I026935
• CAS Number: 307297-40-1
• Molecular Formula: C16H26N4O11
• Molecular Weight: 450.4
• Purity: 95%
• Synonyms: Epitalon (acetate), Epitalon acetate, Epithalone
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Store at -20°C
• IUPAC Name: L-alanyl-L-α-glutamyl-L-α-aspartyl-glycine, monoacetate
• InChI: InChI=1S/C14H22N4O9.C2H4O2/c1-6(15)12(25)17-7(2-3-9(19)20)14(27)18-8(4-10(21)22)13(26)16-5-11(23)24;1-2(3)4/h6-8H,2-5,15H2,1H3,(H,16,26)(H,17,25)(H,18,27)(H,19,20)(H,21,22)(H,23,24);1H3,(H,3,4)/t6-,7-,8-;/m0./s1
• InChIKey: JZJOFRXDMYAPDF-WQYNNSOESA-N
• SMILES: OC(CC[C@H](NC([C@H](C)N)=O)C(N[C@H](C(NCC(O)=O)=O)CC(O)=O)=O)=O.OC(C)=O

Epitalon acetate（Cat No.:I026935）, is a modified form of the peptide Epitalon. It is a synthetic tetrapeptide consisting of the amino acids alanine, glutamic acid, aspartic acid, and glycine. Epitalon acetate is derived from the natural pineal gland peptide epithalamin. This compound has been studied for its potential anti-aging effects and its ability to regulate telomerase activity.

Reference

1. Khavinson, V.K., and Myl’nikov, S.V. Effect of epithalone on the age-specific changes in the time course of lipid peroxidation in Drosophila melanogaster. Bull. Exp. Biol. Med. 130(11), 1116-1119 (2000).
2. Anisimov, V.N., Khavinson, V.K., Popovich, I.G., et al. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology 4(4), 193-202 (2003).
3. Kossoy, G., Anisimov, V.N., Ben-Hur, H., et al. Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice. In Vivo 20(2), 253-257 (2006).
4. Khavinson, V., Goncharova, N., and Lapin, B. Synthetic tetrapeptide epitalon restores disturbed neuroendocrine regulation in senescent monkeys. Neuro. Endocrinol. Lett. 22(4), 251-254 (2001).