For research use only. Not for therapeutic Use.
Epristeride (ONO-9302) is a selective, specific and orally active uncompetitive inhibitor of human steroid 5 alpha-reductase isoform 2. Epristeride has inhibitory effects for SR isoenzymes types 2 with Ki value of 0.7-2 nM. Epristeride can be used for the research of prostatic hyperplasia and acne[1].
Epristeride has inhibitory effects for SR isoenzymes types 2 (SR2) with Ki values of 0.7-2 nM[1].
| Catalog Number | M029061 |
| CAS Number | 119169-78-7 |
| Synonyms | (8S,9S,10R,13S,14S,17S)-17-(tert-butylcarbamoyl)-10,13-dimethyl-2,7,8,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene-3-carboxylic acid |
| Molecular Formula | C25H37NO3 |
| Purity | ≥95% |
| InChI | InChI=1S/C25H37NO3/c1-23(2,3)26-21(27)20-9-8-18-17-7-6-16-14-15(22(28)29)10-12-24(16,4)19(17)11-13-25(18,20)5/h6,14,17-20H,7-13H2,1-5H3,(H,26,27)(H,28,29)/t17-,18-,19-,20+,24-,25-/m0/s1 |
| InChIKey | VAPSMQAHNAZRKC-PQWRYPMOSA-N |
| SMILES | CC12CCC3C(C1CCC2C(=O)NC(C)(C)C)CC=C4C3(CCC(=C4)C(=O)O)C |
| Reference | [1]. M A Levy, et al. Epristeride is a selective and specific uncompetitive inhibitor of human steroid 5 alpha-reductase isoform 2. J Steroid Biochem Mol Biol. 1994 Feb;48(2-3):197-206. |
