EPZ004777 hydrochloride

• CAT Number: I001466
• CAS Number: 1380316-03-9
• Molecular Formula: C28H41N7O4.HCl
• Molecular Weight: 576.13
• Purity: ≥95%
• Synonyms: 1-[3-[[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxyoxolan-2-yl]methyl-propan-2-ylamino]propyl]-3-(4-tert-butylphenyl)urea;hydrochloride
• Target: Histone Methyltransferase
• Solubility: 10 mM in DMSO
• Storage: 4°C, protect from light
• IC50: 0.4 nM
• InChI: InChI=1S/C28H41N7O4.ClH/c1-17(2)34(13-6-12-30-27(38)33-19-9-7-18(8-10-19)28(3,4)5)15-21-22(36)23(37)26(39-21)35-14-11-20-24(29)31-16-32-25(20)35;/h7-11,14,16-17,21-23,26,36-37H,6,12-13,15H2,1-5H3,(H2,29,31,32)(H2,30,33,38);1H/t21-,22-,23-,26-;/m1./s1
• InChIKey: NPEPLDAFAVXSBD-XRJUUMFPSA-N
• SMILES: CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)C[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=CC4=C(N=CN=C43)N)O)O.Cl

EPZ004777 hydrochloride（Cat No.:I001466） is a selective inhibitor of lysine-specific demethylase 1 (LSD1), an enzyme involved in the regulation of gene expression through histone modifications. It acts by binding to the catalytic domain of LSD1, inhibiting its demethylase activity. EPZ004777 hydrochloride has demonstrated potent antiproliferative activity against cancer cells, particularly in leukemia and neuroblastoma models. It is being investigated as a potential therapeutic agent for the treatment of various cancers and other diseases associated with dysregulated histone methylation.

Reference

[1]. Daigle SR, et al. Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. Cancer Cell. 2011 Jul 12;20(1):53-65.

[2]. Chen L, et al. Abrogation of MLL-AF10 and CALM-AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l. Leukemia. 2013 Apr;27(4):813-22.

[3]. Deshpande AJ, et al. Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l.Blood. 2013 Mar 28;121(13):2533-41.