For research use only. Not for therapeutic Use.
ER-819762 is a highly selective, and orally available antagonist of the prostaglandin EP4 receptor (IC50 value of 70 nM). Oral administration of ER-819762 to DBA/1 mice can effectively suppress disease in collagen-induced arthritis (CIA) or glucose-6-phosphate isomerase (GPI)-induced arthritis models. ER-819762 was also effective in treating chronic inflammatory pain in a rat model.
| Catalog Number | I006699 |
| CAS Number | 1155773-15-1 |
| Molecular Formula | C30H39N3O3 |
| Purity | ≥95% |
| IUPAC Name | (5S)-1'-[(3,5-dimethylphenyl)methyl]-2-ethyl-6,8-dimethoxy-5-methylspiro[5,10-dihydroimidazo[1,5-b][2]benzazepine-3,4'-piperidine]-1-one |
| InChI | InChI=1S/C30H39N3O3/c1-7-33-29(34)32-19-24-16-25(35-5)17-26(36-6)28(24)22(4)15-27(32)30(33)8-10-31(11-9-30)18-23-13-20(2)12-21(3)14-23/h12-17,22H,7-11,18-19H2,1-6H3/t22-/m0/s1 |
| SMILES | CCN1C(=O)N2CC3=C([C@H](C=C2C14CCN(CC4)CC5=CC(=CC(=C5)C)C)C)C(=CC(=C3)OC)OC |
| Reference | Q Chen et al. A novel antagonist of the prostaglandin E(2) EP(4) receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models. Br J Pharmacol. 2010 May;160(2):292-310. |
