For research use only. Not for therapeutic Use.
ER176 is a next generation PET radioligand for imaging 18 kDa translocator protein (TSPO), a biomarker for neuroinflammation[1][2].
ER176 shows homozygous high-affinity binders (HABs)/heterozygous mixed affinity binders (MABs) ratio for BP ND (specific-to-non-displaceable ratio of distribution volumes) of 1.2[1].
| Catalog Number | R072267 |
| CAS Number | 1373887-29-6 |
| Synonyms | N-[(2R)-butan-2-yl]-4-(2-chlorophenyl)-N-methylquinazoline-2-carboxamide |
| Molecular Formula | C20H20ClN3O |
| Purity | ≥95% |
| InChI | InChI=1S/C20H20ClN3O/c1-4-13(2)24(3)20(25)19-22-17-12-8-6-10-15(17)18(23-19)14-9-5-7-11-16(14)21/h5-13H,4H2,1-3H3/t13-/m1/s1 |
| InChIKey | ASFLYNMYGAYKON-CYBMUJFWSA-N |
| SMILES | CCC(C)N(C)C(=O)C1=NC2=CC=CC=C2C(=N1)C3=CC=CC=C3Cl |
| Reference | [1]. Masahiro Fujita, et al. Comparison of four 11 C-labeled PET ligands to quantify translocator protein 18 kDa (TSPO) in human brain: (R)-PK11195, PBR28, DPA-713, and ER176-based on recent publications that measured specific-to-non-displaceable ratios. EJNMM [2]. Jason C Mixdorf, et al. Alternative strategies for the synthesis of [ 11 C]ER176 for PET imaging of neuroinflammation. Appl Radiat Isot. 2021 Sep 17;178:109954. |
