ERAP1-IN-1

• CAT Number: I017353
• CAS Number: 865273-97-8
• Molecular Formula: C₂₀H₂₁F₃N₂O₅S
• Molecular Weight: 458.45
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: 4-methoxy-3-[[2-piperidin-1-yl-5-(trifluoromethyl)phenyl]sulfamoyl]benzoic acid
• InChI: InChI=1S/C20H21F3N2O5S/c1-30-17-8-5-13(19(26)27)11-18(17)31(28,29)24-15-12-14(20(21,22)23)6-7-16(15)25-9-3-2-4-10-25/h5-8,11-12,24H,2-4,9-10H2,1H3,(H,26,27)
• InChIKey: NDYXAJZYGMHQDN-UHFFFAOYSA-N
• SMILES: COC1=C(C=C(C=C1)C(=O)O)S(=O)(=O)NC2=C(C=CC(=C2)C(F)(F)F)N3CCCCC3

ERAP1-IN-1(CAT: I017353) operates as an inhibitor of endoplasmic reticulum aminopeptidase 1 (ERAP1). Through competitive inhibition, it curbs ERAP1’s activity concerning a representative nonamer peptide, mimicking physiological substrates. Additionally, ERAP1-IN-1, identified as compound 3, introduces allosteric activation of ERAP1, enhancing its hydrolysis of fluorogenic and chromogenic amino acid substrates. Notably, within the cellular context, ERAP1-IN-1 at 50 µM showcases targeted inhibition of ERAP1. This compound’s nuanced interactions with ERAP1 elucidate its potential role in modulating peptide processing pathways, which could have implications in therapeutic interventions targeting immune responses and peptide presentation pathways.