For research use only. Not for therapeutic Use.
Erastin(CAT: I004132) is a small molecule known for its ability to induce ferroptosis, a form of regulated cell death distinct from apoptosis, characterized by iron-dependent lipid peroxidation. It targets the cystine/glutamate antiporter (system Xc-) and inhibits the uptake of cystine, which is essential for the synthesis of glutathione, a key antioxidant in cells. This leads to an accumulation of reactive oxygen species (ROS) and oxidative stress, ultimately causing cell death. Erastin is widely studied in cancer research, as cancer cells, particularly those with certain oncogenic mutations like RAS, are more susceptible to ferroptosis. Its role in promoting ferroptosis makes Erastin a valuable tool for exploring new therapeutic strategies, particularly in targeting drug-resistant cancers.
| Catalog Number | I004132 |
| CAS Number | 571203-78-6 |
| Synonyms | 2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone |
| Molecular Formula | C30H31ClN4O4 |
| Purity | ≥95% |
| Target | VDAC-2 |
| Solubility | DMSO: ≤ 6.4 mg/mL (Need ultrasonic) |
| Storage | -20°C |
| IC50 | 0.1 uM (VDAC-2) [1] |
| InChIKey | BKQFRNYHFIQEKN-UHFFFAOYSA-N |
