Eritoran Tetrasodium

• CAT Number: I006702
• CAS Number: 185954-98-7
• Molecular Formula: C66H122N2Na4O19P2
• Molecular Weight: 1401.60
• Purity: ≥95%
• Synonyms: B-1287; E-5564; B1287; E5564; B 1287; E 5564;Tetrasodium [(2R,3R,4R,5S,6R)-4-decoxy-5-hydroxy-6-[[(2R,3R,4R,5S,6R)-4-[(3R)-3-methoxydecoxy]-6-(methoxymethyl)-3-[[(Z)-octadec-11-enoyl]amino]-5-phosphonatooxyoxan-2-yl]oxymethyl]-3-(3-oxotetradecanoylam
• Target: Immunology/Inflammation
• Solubility: Soluble in DMSO
• Storage: 0 - 4°C for short term or -20 °C for long term
• IUPAC Name: tetrasodium;[(2R,3R,4R,5S,6R)-4-decoxy-5-hydroxy-6-[[(2R,3R,4R,5S,6R)-4-[(3R)-3-methoxydecoxy]-6-(methoxymethyl)-3-[[(Z)-octadec-11-enoyl]amino]-5-phosphonatooxyoxan-2-yl]oxymethyl]-3-(3-oxotetradecanoylamino)oxan-2-yl] phosphate
• InChI: InChI=1S/C66H126N2O19P2.4Na/c1-7-11-15-19-22-25-26-27-28-29-30-32-34-38-42-46-57(70)67-60-64(82-49-47-54(80-6)45-41-36-18-14-10-4)62(86-88(73,74)75)56(51-79-5)85-65(60)83-52-55-61(72)63(81-48-43-39-35-24-21-17-13-9-3)59(66(84-55)87-89(76,77)78)68-58(71)50-53(69)44-40-37-33-31-23-20-16-12-8-2;;;;/h25-26,54-56,59-66,72H,7-24,27-52H2,1-6H3,(H,67,70)(H,68,71)(H2,73,74,75)(H2,76,77,78);;;;/q;4*+1/p-4/b26-25-;;;;/t54-,55-,56-,59-,60-,61-,62-,63-,64-,65-,66-;;;;/m1..../s1
• InChIKey: FEMINZOAAWPBPP-RHMAUSBNSA-J
• SMILES: CCCCCCCCCCCC(=O)CC(=O)NC1C(C(C(OC1OP(=O)([O-])[O-])COC2C(C(C(C(O2)COC)OP(=O)([O-])[O-])OCCC(CCCCCCC)OC)NC(=O)CCCCCCCCCC=CCCCCCC)O)OCCCCCCCCCC.[Na+].[Na+].[Na+].[Na+]

Eritoran Tetrasodium(CAT: I006702) is a synthetic lipid A analog that functions as a toll-like receptor 4 (TLR4) antagonist, blocking the pro-inflammatory signaling cascade triggered by lipopolysaccharides (LPS) from Gram-negative bacteria. This compound has been studied for its potential in treating sepsis and other conditions associated with excessive inflammation caused by bacterial endotoxins. By inhibiting TLR4 activation, Eritoran Tetrasodium reduces the release of inflammatory cytokines, helping to prevent septic shock and systemic inflammatory responses. It is a promising candidate in research focused on immunomodulation, particularly for conditions characterized by uncontrolled inflammatory responses, such as sepsis and autoimmune diseases.