For research use only. Not for therapeutic Use.
ERK-IN-4 is an ERK inhibitor binds preferentially to ERK2 with a Kd of 5 μM. ERK-IN-4 specificity inhibits ERK Rsk-1 and Elk-1 phosphorylation. ERK-IN-4 has little effect on ERK protein phosphorylation by its upstream activator MEK1/2[1].
ERK-IN-4 (Compound 76; 10-75 µM; 10 days) completely inhibits cell proliferation, and decreases number of cell colonies[1].
ERK-IN-4 (Compound 76; 100 µM) inhibits ERK-mediated phosphorylation of Rsk-1 on Thr573 and ERK-mediated Elk-1 phosphorylation in HeLa cells[1].
| Catalog Number | R065139 |
| CAS Number | 1049738-54-6 |
| Synonyms | (5Z)-3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione;hydrochloride |
| Molecular Formula | C14H17ClN2O3S |
| Purity | ≥95% |
| InChI | InChI=1S/C14H16N2O3S.ClH/c1-2-19-11-5-3-10(4-6-11)9-12-13(17)16(8-7-15)14(18)20-12;/h3-6,9H,2,7-8,15H2,1H3;1H/b12-9-; |
| InChIKey | PQVLWVGMXJPJLG-MWMYENNMSA-N |
| SMILES | CCOC1=CC=C(C=C1)C=C2C(=O)N(C(=O)S2)CCN.Cl |
| Reference | [1]. Chad N Hancock, et al. Identification of novel extracellular signal-regulated kinase docking domain inhibitors. J Med Chem. 2005 Jul 14;48(14):4586-95. |
