ERK5-IN-5

• CAT Number: I040551
• CAS Number: 2318792-30-0
• Molecular Formula: C19H16ClN3O
• Molecular Weight: 337.80
• Purity: ≥95%
• Synonyms: (4-chlorophenyl)-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-3,6-dihydro-2H-pyridin-1-yl]methanone
• InChI: InChI=1S/C19H16ClN3O/c20-15-5-3-14(4-6-15)19(24)23-10-7-13(8-11-23)17-12-22-18-16(17)2-1-9-21-18/h1-7,9,12H,8,10-11H2,(H,21,22)
• InChIKey: NPYUZOWNGDUZMF-UHFFFAOYSA-N
• SMILES: C1CN(CC=C1C2=CNC3=C2C=CC=N3)C(=O)C4=CC=C(C=C4)Cl

ERK5-IN-5 (Cat No.: I040551) is a selective small-molecule inhibitor of extracellular signal-regulated kinase 5 (ERK5), a member of the mitogen-activated protein kinase (MAPK) family involved in cell proliferation, survival, differentiation, and inflammation. By blocking ERK5 activity, ERK5-IN-5 disrupts key signaling pathways associated with cancer progression, inflammatory diseases, and cardiovascular conditions. It is primarily used in preclinical research to study the functional role of ERK5 in oncogenic and stress-related pathways, and to evaluate its potential as a therapeutic target in targeted cancer therapy.

Reference

[1]. Qin Zhang, et al. Design, synthesis and SAR of novel 7-azaindole derivatives as potential Erk5 kinase inhibitor with anticancer activity. Bioorg Med Chem. 2023 Oct 14:95:117503.
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