Erythromycin Ethylsuccinate

• CAT Number: A000689
• CAS Number: 1264-62-6
• Molecular Formula: C43H75NO16
• Molecular Weight: 862.05
• Purity: ≥95%
• Target: Autophagy
• Storage: 3 years -20C powder
• IUPAC Name: 4-O-[(2S,3R,4S,6R)-4-(dimethylamino)-2-[[(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-oxacyclotetradec-6-yl]oxy]-6-methyloxan-3-yl] 1-O-ethyl butanedioate
• InChI: InChI=1S/C43H75NO16/c1-15-29-43(11,52)36(48)24(5)33(47)22(3)20-41(9,51)38(25(6)34(26(7)39(50)57-29)59-32-21-42(10,53-14)37(49)27(8)56-32)60-40-35(28(44(12)13)19-23(4)55-40)58-31(46)18-17-30(45)54-16-2/h22-29,32,34-38,40,48-49,51-52H,15-21H2,1-14H3/t22-,23-,24+,25+,26-,27+,28+,29-,32+,34+,35-,36-,37+,38-,40+,41-,42-,43-/m1/s1
• InChIKey: NSYZCCDSJNWWJL-YXOIYICCSA-N
• SMILES: CC[C@@H]1[C@@]([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)OC(=O)CCC(=O)OCC)(C)O)C)C)O)(C)O

Erythromycin Ethylsuccinate（Cat No.:A000689）is a modified form of erythromycin, designed for improved oral bioavailability and palatability, making it especially suitable for pediatric and adult patients who may have difficulty swallowing traditional antibiotics. It belongs to the macrolide class and works by inhibiting bacterial protein synthesis, effectively treating a range of bacterial infections, including respiratory tract infections, skin infections, and pertussis. The ethylsuccinate ester enhances its stability in the acidic environment of the stomach, allowing for better absorption. This formulation offers a reliable option for treating infections with convenient dosing.

Reference

Lovmar, Martin, and Tanel Tenson. /The Mechanism of Action of Macrolides, Lincosamides and Streptogramin B Reveals the Nascent Peptide Exit Path in the Ribosome./Journal of Molecular Microbiology 330.5 (2003): 1005-014.