Esaxerenone

• CAT Number: I011901
• CAS Number: 1632006-28-0
• Molecular Formula: C22H21F3N2O4S
• Molecular Weight: 466.4752
• Purity: ≥95%
• Synonyms: Esaxerenone; CS-3150; CS 3150; CS3150; XL-550; XL550; XL 550.;1-(2-hydroxyethyl)-4-methyl-N-(4-(methylsulfonyl)phenyl)-5-(2-(trifluoromethyl)phenyl)-1H-pyrrole-3-carboxamide
• Target: aldosterone receptor antagonist
• Solubility: Soluble in DMSO, not in water
• Storage: Store at 0-8 °C
• IUPAC Name: 1-(2-hydroxyethyl)-4-methyl-N-(4-methylsulfonylphenyl)-5-[2-(trifluoromethyl)phenyl]pyrrole-3-carboxamide
• InChI: InChI=1S/C22H21F3N2O4S/c1-14-18(21(29)26-15-7-9-16(10-8-15)32(2,30)31)13-27(11-12-28)20(14)17-5-3-4-6-19(17)22(23,24)25/h3-10,13,28H,11-12H2,1-2H3,(H,26,29)
• InChIKey: NOSNHVJANRODGR-UHFFFAOYSA-N
• SMILES: CS(C1=CC=C(NC(C2=CN(CCO)C(C3=CC=CC=C3C(F)(F)F)=C2C)=O)C=C1)(=O)=O

Esaxerenone (Cat.No:I011901), also known as CS-3150, XL-550, is a nonsteroidal antimineralocorticoid which was discovered by Exelixis and is now under development by Daiichi Sankyo Company for the treatment of hypertension, essential hypertension, hyperaldosteronism, and diabetic nephropathies. It acts as a highly selective silent antagonist of the mineralocorticoid receptor (MR), the receptor for aldosterone, with greater than 1,000-fold selectivity for this receptor over other steroid hormone receptors, and 4-fold and 76-fold higher affinity for the MR relative to the existing antimineralocorticoids spironolactone and eplerenone.