Escitalopram Oxalate

For research use only. Not for therapeutic Use.

  • CAT Number: A000710
  • CAS Number: 219861-08-2
  • Molecular Formula: C22H23FN2O5
  • Molecular Weight: 414.43
  • Purity: ≥95%
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Escitalopram Oxalate(Cat No.:A000710)is a selective serotonin reuptake inhibitor (SSRI) widely used to treat depression and anxiety disorders. It works by increasing serotonin levels in the brain, enhancing mood regulation and reducing symptoms of depression, generalized anxiety disorder, and panic disorder. As the S-enantiomer of citalopram, Escitalopram offers more potent and selective serotonin reuptake inhibition with fewer side effects compared to other SSRIs. It is well-tolerated and often preferred for its efficacy in improving emotional stability and its relatively low incidence of adverse reactions, such as weight gain or sedation.


Catalog Number A000710
CAS Number 219861-08-2
Synonyms

219861-08-2; Lexapro; Cipralex; (S)-Citalopram Oxalate; Escitalopram (oxalate)

Molecular Formula C22H23FN2O5
Purity ≥95%
Target Serotonin Transporter
Solubility Soluble in DMSO > 10 mM
Storage -20°C
IUPAC Name (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3H-2-benzofuran-5-carbonitrile;oxalic acid
InChI InChI=1S/C20H21FN2O.C2H2O4/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;3-1(4)2(5)6/h4-9,12H,3,10-11,14H2,1-2H3;(H,3,4)(H,5,6)/t20-;/m0./s1
InChIKey KTGRHKOEFSJQNS-BDQAORGHSA-N
SMILES CN(C)CCC[C@@]1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F.C(=O)(C(=O)O)O
Reference

1: Chen VC, Hsieh YH, Chen LJ, Hsu TC, Tzang BS. Escitalopram oxalate induces
apoptosis in U-87MG cells and autophagy in GBM8401 cells. J Cell Mol Med. 2017
Nov 3. doi: 10.1111/jcmm.13372. [Epub ahead of print] PubMed PMID: 29105282.
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2: Attia K Ali, Mohamed AM, Fekry MA. Electroanalytical Determination of
Escitalopram Oxalate Using Nickel Nanoparticles Modified Carbon Paste Sensor.
Acta Chim Slov. 2017 Jun;64(2):415-421. PubMed PMID: 28621385.

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3: Sheladia S, Patel B. Determination of Escitalopram Oxalate and L-Methylfolate
in Tablet by Spectrophotometric and Reverse Phase High-Performance Liquid
Chromatographic Methods. J Chromatogr Sci. 2017 May 1;55(5):550-555. doi:
10.1093/chromsci/bmx008. PubMed PMID: 28203815.
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4: Ma L, Lu ZN, Hu P, Yao CJ. Neuroprotective effect of escitalopram oxalate in
rats with chronic hypoperfusion. J Huazhong Univ Sci Technolog Med Sci. 2015
Aug;35(4):514-8. doi: 10.1007/s11596-015-1462-x. Epub 2015 Jul 31. PubMed PMID:
26223919.
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5: Khanna S, Chirinos RE, Venna S. Escitalopram oxalate (Lexapro)-induced
acneiform eruption. J Am Acad Dermatol. 2012 Dec;67(6):e261-3. doi:
10.1016/j.jaad.2012.03.032. PubMed PMID: 23158626.
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6: Kakde RB, Satone DD, Gadapayale KK, Kakde MG. Stability-indicating RP-HPLC
method for the simultaneous determination of escitalopram oxalate and clonazepam.
J Chromatogr Sci. 2013 Jul;51(6):490-5. doi: 10.1093/chromsci/bms177. Epub 2012
Nov 7. PubMed PMID: 23135233.

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7: Alarfaj NA, Aly FA, Al-Qahtany AA. Flow-injection chemiluminescence and
electrogenerated chemiluminescence determination of escitalopram oxalate in
tablet form. Luminescence. 2013 Jan-Feb;28(1):84-92. doi: 10.1002/bio.2372. Epub
2012 May 4. PubMed PMID: 22555899.

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8: Dikmen M, Cantürk Z, Oztürk Y. Escitalopram oxalate, a selective serotonin
reuptake inhibitor, exhibits cytotoxic and apoptotic effects in glioma C6 cells.
Acta Neuropsychiatr. 2011 Aug;23(4):173-8. doi: 10.1111/j.1601-5215.2011.00550.x.
PubMed PMID: 25379795.
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9: Sharma S, Rajpurohit H, Sonwal C, Bhandari A, Choudhary V, Jain T. Zero order
spectrophotometric method for estimation of escitalopram oxalate in tablet
formulations. J Young Pharm. 2010 Oct;2(4):420-3. doi: 10.4103/0975-1483.71626.
PubMed PMID: 21264107; PubMed Central PMCID: PMC3019386.

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10: Vetrichelvan T, Arul K, Sumithra M, Umadevi B. Colorimetric method for the
estimation of escitalopram oxalate in tablet dosage form. Indian J Pharm Sci.
2010 Mar;72(2):269-71. doi: 10.4103/0250-474X.65011. PubMed PMID: 20838541;
PubMed Central PMCID: PMC2929796.

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