For research use only. Not for therapeutic Use.
Esculin is a coumarin glucoside that naturally occurs in the horse chestnut (Aesculus hippocastanum), California Buckeye (Aesculus californica), Prickly Box (Bursaria spinosa) and in daphnin (the dark green resin of Daphne mezereum). It is also found in dandelion coffee. Aesculin is used in a microbiology laboratory to aid in the identification of bacterial species (especially Enterococci and Listeria). In fact, all strains of Group D Streptococci hydrolyze æsculin in 40% bile. (Source: http://en.wikipedia.org/wiki/Esculin).
| Catalog Number | R010508 |
| CAS Number | 531-75-9 |
| Molecular Formula | C15H16O9 |
| Purity | ≥95% |
| Target | p38 MAPK |
| Storage | 3 years -20C powder |
| IUPAC Name | 7-hydroxy-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one |
| InChI | InChI=1S/C15H16O9/c16-5-10-12(19)13(20)14(21)15(24-10)23-9-3-6-1-2-11(18)22-8(6)4-7(9)17/h1-4,10,12-17,19-21H,5H2/t10-,12-,13+,14-,15-/m1/s1 |
| InChIKey | XHCADAYNFIFUHF-TVKJYDDYSA-N |
| SMILES | C1=CC(=O)OC2=CC(=C(C=C21)OC3C(C(C(C(O3)CO)O)O)O)O |
| Reference | </br>1:Simultaneous determination of anemoside B4, phellodendrine, berberine, palmatine, obakunone, esculin, esculetin in rat plasma by UPLC-ESI-MS/MS and its application to a comparative pharmacokinetic study in normal and ulcerative colitis rats. Yang L, Meng X, Yu X, Kuang H.J Pharm Biomed Anal. 2017 Feb 5;134:43-52. doi: 10.1016/j.jpba.2016.11.021. Epub 2016 Nov 11. PMID: 27875787 </br>2:Gastroprotective effect of esculin on ethanol-induced gastric lesion in mice. Li W, Wang Y, Wang X, Zhang H, He Z, Zhi W, Liu F, Niu X.Fundam Clin Pharmacol. 2017 Apr;31(2):174-184. doi: 10.1111/fcp.12255. Epub 2017 Jan 15. PMID: 27873354 </br>3:Genotoxic and anti-genotoxic effects of esculin and its oligomer fractions against mitomycin C-induced DNA damages in mice. Mokdad Bzeouich I, Mustapha N, Maatouk M, Ghedira K, Ghoul M, Chekir-Ghedira L.Regul Toxicol Pharmacol. 2016 Dec;82:48-52. doi: 10.1016/j.yrtph.2016.11.002. Epub 2016 Nov 4. PMID: 27825835 </br>4:Esculin attenuates endotoxin shock induced by lipopolysaccharide in mouse and NO production in vitro through inhibition of NF-κB activation. Li W, Wang Y, Wang X, He Z, Liu F, Zhi W, Zhang H, Niu X.Eur J Pharmacol. 2016 Nov 15;791:726-734. doi: 10.1016/j.ejphar.2016.10.013. Epub 2016 Oct 13. PMID: 27746168 </br>5:Metabolic profile of esculin in rats by ultra high performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry. Wang Y, Zhao M, Ou Y, Zeng B, Lou X, Wang M, Zhao C.J Chromatogr B Analyt Technol Biomed Life Sci. 2016 May 1;1020:120-8. doi: 10.1016/j.jchromb.2016.03.027. Epub 2016 Mar 21. PMID: 27038404 </br>6:Clostridium difficile Ribotype 023 Lacks the Ability To Hydrolyze Esculin, Leading to False-Negative Results on Chromogenic Agar. Connor MC, Fairley DJ, McKenna JP, Marks NJ, McGrath JW.J Clin Microbiol. 2016 May;54(5):1404-5. doi: 10.1128/JCM.00234-16. Epub 2016 Mar 9. No abstract available. PMID: 26962090 Free PMC Article</br>7:Protective effect of Esculin in adjuvant-induced arthritic (AIA) rats via attenuating pro-inflammatory cytokines and oxidative stress. Zheng L, Yang L, Wang Z, Chen C, Su Y.Cell Mol Biol (Noisy-le-grand). 2015 Nov 8;61(7):1-5. PMID: 26567597 </br>8:Esculin improves dyslipidemia, inflammation and renal damage in streptozotocin-induced diabetic rats. Wang YH, Liu YH, He GR, Lv Y, Du GH.BMC Complement Altern Med. 2015 Nov 9;15:402. doi: 10.1186/s12906-015-0817-y. PMID: 26552745 Free PMC Article</br>9:Esculin and its oligomer fractions inhibit adhesion and migration of U87 glioblastoma cells and in vitro angiogenesis. Mokdad-Bzeouich I, Kovacic H, Ghedira K, Chebil L, Ghoul M, Chekir-Ghedira L, Luis J.Tumour Biol. 2016 Mar;37(3):3657-64. doi: 10.1007/s13277-015-4209-1. Epub 2015 Oct 12. PMID: 26459313 </br>10:Esculin exhibited anti-inflammatory activities in vivo and regulated TNF-α and IL-6 production in LPS-stimulated mouse peritoneal macrophages in vitro through MAPK pathway. Niu X, Wang Y, Li W, Zhang H, Wang X, Mu Q, He Z, Yao H.Int Immunopharmacol. 2015 Dec;29(2):779-86. doi: 10.1016/j.intimp.2015.08.041. Epub 2015 Sep 26. PMID: 26391063 |
