For research use only. Not for therapeutic Use.
Estazolam is a benzodiazepine with anxiolytic, anticonvulsant, hypnotic, and muscle relaxant properties. Estazolam binds to the gamma-aminobutyric acid (GABA) receptor at a site distinct from the inhibitory neurotransmitter GABA binding site in the limbic system of the central nervous system. This binding leads to an opening of the chloride channels, which allows the flow of chloride ions into the neuron, hyperpolarizes the neuronal membrane, inhibits neuronal firing, and leads to a decrease in neuronal excitability.
| Catalog Number | I006718 |
| CAS Number | 29975-16-4 |
| Synonyms | Estazolam; Eurodin; Nuctalon; ProSom; Esilgan; Julodin; Nuctalon; ProSom; Takeda Brand of Estazolam; Tasedan;;8-chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine |
| Molecular Formula | C16H11ClN4 |
| Purity | ≥95% |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4°C for short term or -20 °C for long term |
| IUPAC Name | 8-chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine |
| InChI | InChI=1S/C16H11ClN4/c17-12-6-7-14-13(8-12)16(11-4-2-1-3-5-11)18-9-15-20-19-10-21(14)15/h1-8,10H,9H2 |
| InChIKey | CDCHDCWJMGXXRH-UHFFFAOYSA-N |
| SMILES | C1C2=NN=CN2C3=C(C=C(C=C3)Cl)C(=N1)C4=CC=CC=C4 |
| Reference | </br>1:Investigation of the binding interaction between estazolam and bovine serum albumin: multi-spectroscopic methods and molecular docking technique. Zhang YF, Zhou KL, Lou YY, Pan DQ, Shi JH.J Biomol Struct Dyn. 2016 Dec 23:1-10. doi: 10.1080/07391102.2016.1264889. [Epub ahead of print] No abstract available. PMID: 27882826 </br>2:Dependence, misuse, and beliefs regarding use of hypnotics by elderly psychiatric patients taking zolpidem, estazolam, or flunitrazepam. Yen CF, Ko CH, Chang YP, Yu CY, Huang MF, Yeh YC, Lin JJ, Chen CS.Asia Pac Psychiatry. 2015 Sep;7(3):298-305. doi: 10.1111/appy.12147. Epub 2014 Oct 8. PMID: 25296384 </br>3:Clinical efficacies of treating refractory insomnia patients with estazolam plus alternating current magnetic field. Wang ZZ, Wang YP, Yang B, Wan JP, Wang J.Chin Med J (Engl). 2012 Sep;125(17):3175-6. No abstract available. PMID: 22932202 </br>4:[Stability of estazolam in dog tissues preserved in formaldehyde solution]. Yuan JX, Wang YJ, Yun KM.Fa Yi Xue Za Zhi. 2011 Apr;27(2):117-9, 124. Chinese. PMID: 21604450 </br>5:[The influence of estazolam on human neurobehavioral function]. Bu J, Zhuo XY.Fa Yi Xue Za Zhi. 2010 Feb;26(1):30-2. Chinese. PMID: 20232740 </br>6:[Analysis on somnipathy related factors in elderly patients with stroke and comparative study on the efficacy of treatment by traditional Chinese medicine and by estazolam]. Li HC, Chen XG, Tian X.Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 Mar;29(3):204-7. Chinese. PMID: 19548433 </br>7:Comparative bioavailability of two estazolam tablet formulations in Indonesian healthy volunteers. Harahap Y, Sasongko L, Prasaja B, Indriati E, Lusthom W, Lipin.Arzneimittelforschung. 2008;58(10):501-4. doi: 10.1055/s-0031-1296548. PMID: 19025059 </br>8:[Comparative study on treatment of somnipathy in patients with hypertension by traditional Chinese medicine and by estazolam]. Li HC, Yang YL, Ma M.Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007 Feb;27(2):123-6. Chinese. PMID: 17342998 </br>9:[Effects of midazolam and estazolam as hypnotics in hypertensive patients with chronic insomnia: a multicentre, open labeled, randomized clinical trial]. Wang XL, Ke YN; Midazolam Trenting Hypentension with Insomnia Study Group..Zhonghua Xin Xue Guan Bing Za Zhi. 2006 Apr;34(4):338-40. Chinese. PMID: 16776928 </br>10:Identification of human cytochrome P450 enzymes involved in the formation of 4-hydroxyestazolam from estazolam. Miura M, Otani K, Ohkubo T.Xenobiotica. 2005 May;35(5):455-65. PMID: 16012077 |
