Estradiol-d5

• CAT Number: S000855
• CAS Number: 221093-45-4
• Molecular Formula: C18H19D5O2
• Molecular Weight: 277.41
• Purity: ≥95%
• Target: Metabolic Enzyme/Protease
• IUPAC Name: (8R,9S,13S,14S,17S)-2,4,16,16,17-pentadeuterio-13-methyl-6,7,8,9,11,12,14,15-octahydrocyclopenta[a]phenanthrene-3,17-diol
• InChI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1/i3D,7D2,10D,17D
• InChIKey: VOXZDWNPVJITMN-MOKSCAJFSA-N
• SMILES: [2H]C1=CC2=C(CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC([C@]4([2H])O)([2H])[2H])C)C(=C1O)[2H]

Estradiol-d5（Cat No.:S000855）is a deuterated form of estradiol, a potent estrogen hormone crucial for regulating various physiological functions, particularly in the female reproductive system. The “d5” designation indicates that five hydrogen atoms in the estradiol molecule have been replaced with deuterium, a stable isotope of hydrogen. This isotopic labeling is used in research to track the hormone’s metabolism, distribution, and interactions in biological systems. Estradiol-d5 is often employed in pharmacokinetic studies, hormone research, and clinical assays to investigate estradiol’s role in hormone therapies, metabolic pathways, and disease processes like breast cancer.

Reference

[1]. Harburger LL, et al. Dose-dependent effects of post-training estradiol plus progesterone treatment on object memory consolidation and hippocampal extracellular signal-regulated kinase activation in young ovariectomized mice. Neuroscience. 2009;160(1):6-12.
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[3]. Quanfu Huang, et al. 17β-estradiol Upregulates IL6 Expression Through the ERβ Pathway to Promote Lung Adenocarcinoma Progression. J Exp Clin Cancer Res. 2018 Jul 3;37(1):133.
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[4]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
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[5]. Woolley CS, et al. Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: correlation with dendritic spine density. J Neurosci. 1997 Mar 1;17(5):1848-59.
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[6]. Woolley CS, et al. Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. J Neurosci. 1992 Jul;12(7):2549-54.
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[7]. Woolley CS, et al. Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat. J Comp Neurol. 1993 Oct 8;336(2):293-306.
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