Estradiol valerate

For research use only. Not for therapeutic Use.

  • CAT Number: A001096
  • CAS Number: 979-32-8
  • Molecular Formula: C23H32O3
  • Molecular Weight: 356.5
  • Purity: ≥95%
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Estradiol valerate (CAS 979-32-8) is a synthetic ester, specifically the 17-pentanoyl ester, of the natural estrogen, 17β-estradiol. It was introduced in the 1950s, and along with estradiol benzoate and estradiol cypionate, has since become one of the most widely used esters of estradiol. 


Catalog Number A001096
CAS Number 979-32-8
Synonyms

NA

Molecular Formula C23H32O3
Purity ≥95%
Target Estrogen Receptor/ERR
Solubility >15.5mg/mL in DMSO
Storage 3 years -20C powder
IUPAC Name [(8R,9S,13S,14S,17S)-3-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] pentanoate
InChI InChI=1S/C23H32O3/c1-3-4-5-22(25)26-21-11-10-20-19-8-6-15-14-16(24)7-9-17(15)18(19)12-13-23(20,21)2/h7,9,14,18-21,24H,3-6,8,10-13H2,1-2H3/t18-,19-,20+,21+,23+/m1/s1
InChIKey RSEPBGGWRJCQGY-RBRWEJTLSA-N
SMILES CCCCC(=O)OC1CCC2C1(CCC3C2CCC4=C3C=CC(=C4)O)C
Reference

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1:Mechanisms underlying alterations in norepinephrine levels in the locus coeruleus of ovariectomized rats: Modulation by estradiol valerate and black cohosh. Zhang J, Bai W, Wang W, Jiang H, Jin B, Liu Y, Liu S, Wang K, Jia J, Qin L.Neuroscience. 2017 Apr 27;354:110-121. doi: 10.1016/j.neuroscience.2017.04.029. [Epub ahead of print] PMID: 28457819<br />
2:Changes of The Uterine Tissue in Rats with Polycystic Ovary Syndrome Induced by Estradiol Valerate. Mirabolghasemi G, Kamyab Z.Int J Fertil Steril. 2017 Apr-Jun;11(1):47-55. Epub 2016 Nov 11. PMID: 28367305 Free PMC Article<br />
3:The effects of 6-Gingerol on reproductive improvement, liver functioning and Cyclooxygenase-2 gene expression in estradiol valerate – Induced polycystic ovary syndrome in Wistar rats. Pournaderi PS, Yaghmaei P, Khodaei H, Noormohammadi Z, Hejazi SH.Biochem Biophys Res Commun. 2017 Mar 4;484(2):461-466. doi: 10.1016/j.bbrc.2017.01.057. Epub 2017 Jan 16. PMID: 28093231<br />
4:Corifollitropin stimulation in combination with GnRH-antagonists after estradiol valerate pre-treatment. A pilot study on patientfriendly IVF. Decleer W, Verschueren K, Vandeginste S, Osmanagaoglu K, Devroey P.Facts Views Vis Obgyn. 2015 Dec 28;7(4):223-230. PMID: 27729967 Free PMC Article<br />
5:Continuation rates, bleeding profile acceptability, and satisfaction of women using an oral contraceptive pill containing estradiol valerate and dienogest versus a progestogen-only pill after switching from an ethinylestradiol-containing pill in a real-life setting: results of the CONTENT study. Briggs P, Serrani M, Vogtl&auml;nder K, Parke S.Int J Womens Health. 2016 Sep 15;8:477-487. eCollection 2016. PMID: 27695365 Free PMC Article<br />
6:Comparison of the Effect of Clomiphene- Estradiol Valerate vs Letrozole on Endometrial Thickness, Abortion and Pregnancy Rate in Infertile Women with Polycystic Ovarian Syndrome. Seyedoshohadaei F, Tangestani L, Zandvakili F, Rashadmanesh N.J Clin Diagn Res. 2016 Aug;10(8):QC10-3. doi: 10.7860/JCDR/2016/20954.8324. Epub 2016 Aug 1. PMID: 27656509 Free PMC Article<br />
7:Estradiol Valerate and Remifemin ameliorate ovariectomy-induced decrease in a serotonin dorsal raphe-preoptic hypothalamus pathway in rats. Wang W, Cui G, Jin B, Wang K, Chen X, Sun Y, Qin L, Bai W.Ann Anat. 2016 Nov;208:31-39. doi: 10.1016/j.aanat.2016.08.001. Epub 2016 Aug 22. PMID: 27562857<br />
8:A Comparison of the Effects of Transdermal Estradiol and Estradiol Valerate on Endometrial Receptivity in Frozen-thawed Embryo Transfer Cycles: A Randomized Clinical Trial. Davar R, Janati S, Mohseni F, Khabazkhoob M, Asgari S.J Reprod Infertil. 2016 Apr-Jun;17(2):97-103. PMID: 27141464 Free PMC Article<br />
9:Letrozole vs estradiol valerate induced PCOS in rats: glycemic, oxidative and inflammatory status assessment. Dăneasă A, Cucolaş C, Lenghel LM, Olteanu D, Orăsan R, Filip GA.Reproduction. 2016 Apr;151(4):401-9. doi: 10.1530/REP-15-0352. Epub 2016 Jan 20. PMID: 26792865 Free Article<br />
10:The Effect of Green Tea Extract on Reproductive Improvement in Estradiol Valerate-Induced Polycystic Ovarian Syndrome in Rat. Ghafurniyan H, Azarnia M, Nabiuni M, Karimzadeh L.Iran J Pharm Res. 2015 Fall;14(4):1215-33. PMID: 26664389 Free PMC Article

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