Estriol

• CAT Number: A000212
• CAS Number: 50-27-1
• Molecular Formula: C18H24O3
• Molecular Weight: 288.4
• Purity: ≥95%
• Synonyms: Oestriol; 50-27-1; Estratriol; Ovestin; Ovestrion
• Target: Metabolic Enzyme/Protease
• Solubility: >9.3mg/mL in DMSO
• Storage: -20°C
• InChI: 1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1
• InChIKey: PROQIPRRNZUXQM-ZXXIGWHRSA-N
• SMILES: CC12CCC3C(C1CC(C2O)O)CCC4=C3C=CC(=C4)O

Estriol (CAT: A000212) is a naturally occurring hormone belonging to the class of compounds known as estrogens. Estrogens are predominantly produced by the ovaries during the menstrual cycle and play a crucial role in the development and maintenance of female sexual characteristics and reproductive health.

Reference

1: Wang C, Guan D, Chen C, He S, Liu X, Wang C, Wu H. Rapid detection of
unconjugated estriol in the serum via superparamagnetic lateral flow
immunochromatographic assay. Anal Bioanal Chem. 2017 Nov 2. doi:
10.1007/s00216-017-0699-6. [Epub ahead of print] PubMed PMID: 29098334.

2: Mendes-Bastos P. Plantar keratoderma climatericum: Successful improvement with
a topical estriol cream. J Cosmet Dermatol. 2017 Sep 19. doi: 10.1111/jocd.12422.
[Epub ahead of print] PubMed PMID: 28929614.

3: Otsuka M, Kadokawa H. GPR30 mediates estrone, estriol, and estradiol to
suppress gonadotropin-releasing hormone-induced luteinizing hormone secretion in
the anterior pituitary of heifers. J Reprod Dev. 2017 Oct 18;63(5):519-525. doi:
10.1262/jrd.2017-035. Epub 2017 Aug 6. PubMed PMID: 28781349; PubMed Central
PMCID: PMC5649102.

4: Cruz VL, Steiner ML, Pompei LM, Strufaldi R, Fonseca FLA, Santiago LHS,
Wajsfeld T, Fernandes CE. Randomized, double-blind, placebo-controlled clinical
trial for evaluating the efficacy of fractional CO2 laser compared with topical
estriol in the treatment of vaginal atrophy in postmenopausal women. Menopause.
2017 Jul 31. doi: 10.1097/GME.0000000000000955. [Epub ahead of print] PubMed
PMID: 28763401.

5: Raymundo-Pereira PA, Campos AM, Vicentini FC, Janegitz BC, Mendonça CD, Furini
LN, Boas NV, Calegaro ML, Constantino CJL, Machado SAS, Oliveira ON Jr. Sensitive
detection of estriol hormone in creek water using a sensor platform based on
carbon black and silver nanoparticles. Talanta. 2017 Nov 1;174:652-659. doi:
10.1016/j.talanta.2017.06.058. Epub 2017 Jun 27. PubMed PMID: 28738637.

6: Liu J, Li S, Li X, Gao Y, Ling W. Removal of estrone, 17β-estradiol, and
estriol from sewage and cow dung by immobilized Novosphingobium sp. ARI-1.
Environ Technol. 2017 Jul 27:1-11. doi: 10.1080/09593330.2017.1355935. [Epub
ahead of print] PubMed PMID: 28707514.

7: Ramírez-Sánchez IM, Tuberty S, Hambourger M, Bandala ER. Resource efficiency
analysis for photocatalytic degradation and mineralization of estriol using
TiO(2) nanoparticles. Chemosphere. 2017 Oct;184:1270-1285. doi:
10.1016/j.chemosphere.2017.06.046. Epub 2017 Jun 14. PubMed PMID: 28672726.

8: Rueda C, Osorio AM, Avellaneda AC, Pinzón CE, Restrepo OI. The efficacy and
safety of estriol to treat vulvovaginal atrophy in postmenopausal women: a
systematic literature review. Climacteric. 2017 Aug;20(4):321-330. doi:
10.1080/13697137.2017.1329291. Epub 2017 Jun 16. PubMed PMID: 28622049.

9: Ali ES, Mangold C, Peiris AN. Estriol: emerging clinical benefits. Menopause.
2017 Sep;24(9):1081-1085. doi: 10.1097/GME.0000000000000855. PubMed PMID:
28375935.

10: Caruso S, Cianci S, Vitale SG, Matarazzo MG, Amore FF, Cianci A. Effects of
ultralow topical estriol dose on vaginal health and quality of life in
postmenopausal women who underwent surgical treatment for pelvic organ prolapse.
Menopause. 2017 Aug;24(8):900-907. doi: 10.1097/GME.0000000000000851. PubMed
PMID: 28350758.