ETC-159

• CAT Number: I002134
• CAS Number: 1638250-96-0
• Molecular Formula: C19H17N7O3
• Molecular Weight: 391.38
• Purity: ≥95%
• Target: Wnt
• Solubility: DMSO: ≥ 34 mg/mL
• Storage: Store at -20°C
• IC50: 2.9 nM
• IUPAC Name: 2-(1,3-dimethyl-2,6-dioxopurin-7-yl)-N-(6-phenylpyridazin-3-yl)acetamide
• InChI: 1S/C19H17N7O3/c1-24-17-16(18(28)25(2)19(24)29)26(11-20-17)10-15(27)21-14-9-8-13(22-23-14)12-6-4-3-5-7-12/h3-9,11H,10H2,1-2H3,(H,21,23,27)
• InChIKey: QTRXIFVSTWXRJJ-UHFFFAOYSA-N
• SMILES: CN1C2=C(C(=O)N(C1=O)C)N(C=N2)CC(=O)NC3=NN=C(C=C3)C4=CC=CC=C4

ETC-159 is a potent, selective inhibitor of the mTORC1 and mTORC2 complexes, designed to target the mTOR pathway, which plays a crucial role in cell growth, metabolism, and survival. It has shown promise in preclinical studies for its ability to inhibit tumor growth, particularly in cancers with dysregulated mTOR signaling. ETC-159 is being investigated as a potential therapeutic agent in cancer treatment, offering new opportunities to overcome resistance mechanisms associated with traditional mTOR inhibitors.