Ethambutol

• CAT Number: I004765
• CAS Number: 74-55-5
• Molecular Formula: C10H24N2O2
• Molecular Weight: 204.31
• Purity: ≥95%
• Synonyms: (2S)-2-[2-[[(2S)-1-hydroxybutan-2-yl]amino]ethylamino]butan-1-ol
• Target: Anti-infection
• Solubility: 10 mM in DMSO
• Storage: 2-8°C
• InChI: InChI=1S/C10H24N2O2/c1-3-9(7-13)11-5-6-12-10(4-2)8-14/h9-14H,3-8H2,1-2H3/t9-,10-/m0/s1
• InChIKey: AEUTYOVWOVBAKS-UWVGGRQHSA-N
• SMILES: CCC(CO)NCCNC(CC)CO

Ethambutol（Cat No.:I004765）is an antitubercular antibiotic used primarily in combination therapy to treat Mycobacterium tuberculosis infections. It works by inhibiting arabinosyl transferase, an enzyme crucial for the synthesis of the mycobacterial cell wall, leading to cell wall disruption and bacterial cell death. Ethambutol is effective against both active and latent tuberculosis and is often combined with other drugs like isoniazid or rifampicin to prevent drug resistance. Its selective action against mycobacteria and role in multidrug regimens make ethambutol essential in tuberculosis treatment protocols worldwide.

Reference

[1]. Ethambutol. Tuberculosis (Edinb), 2008. 88(2): p. 102-5.

[2]. Rastogi, N., V. Labrousse, and K.S. Goh, In vitro activities of fourteen antimicrobial agents against drug susceptible and resistant clinical isolates of Mycobacterium tuberculosis and comparative intracellular activities against the virulent H37Rv strain in human macrophages. Curr Microbiol, 1996. 33(3): p. 167-75.

[3]. Kaur, D. and G.K. Khuller, In vitro, ex-vivo and in vivo activities of ethambutol and sparfloxacin alone and in combination against mycobacteria. Int J Antimicrob Agents, 2001. 17(1): p. 51-5.