For research use only. Not for therapeutic Use.
Ethotoin is an anticonvulsant drug used in the treatment of epilepsy. It is a hydantoin, similar to phenytoin. Ethotoin lacks phenytoin/’s side effects of gingival hyperplasia and hirsutism; however, it is less effective. This, combined with the need for frequent dosing has limited its usefulness. Ethotoin is no longer widely used.
| Catalog Number | R039931 |
| CAS Number | 86-35-1 |
| Synonyms | (±)-Ethotoin; 1-Ethyl-2,5-dioxo-4-phenylimidazolidine; 3-Ethyl-5-phenyl-2,4-imidazolidinedione; 3-Ethyl-5-phenylhydantoin; 3-Ethyl-5-phenylimidazolidin-2,4-dione; AC-695; Accenon; Peganone; 3-Ethyl-5-phenyl-2,4-Imidazolidinedione; |
| Molecular Formula | C11H12N2O2 |
| Purity | ≥95% |
| Storage | -20°C |
| IUPAC Name | 3-ethyl-5-phenylimidazolidine-2,4-dione |
| InChI | InChI=1S/C11H12N2O2/c1-2-13-10(14)9(12-11(13)15)8-6-4-3-5-7-8/h3-7,9H,2H2,1H3,(H,12,15) |
| InChIKey | SZQIFWWUIBRPBZ-UHFFFAOYSA-N |
| SMILES | CCN1C(=O)C(NC1=O)C2=CC=CC=C2 |
| Reference | </br>1:Enantioselective pharmacokinetics of ethotoin in humans following single oral doses of the racemate. Hooper WD, O/’Shea NJ, Qing MS.Chirality. 1992;4(3):142-7. PMID: 1350205 </br>2:Comparison of the behavioral teratogenic potential of phenytoin, mephenytoin, ethotoin, and hydantoin in rats. Minck DR, Acuff-Smith KD, Vorhees CV.Teratology. 1991 Apr;43(4):279-93. PMID: 1675495 </br>3:Adjunctive therapy for intractable epilepsy with ethotoin. Biton V, Gates JR, Ritter FJ, Loewenson RB.Epilepsia. 1990 Jul-Aug;31(4):433-7. PMID: 1973383 </br>4:A pharmacokinetic rationale for three times daily administration of ethotoin (Peganone). Browne TR, Szabo GK.J Clin Pharmacol. 1989 Mar;29(3):270-1. No abstract available. PMID: 2566627 </br>5:Stereoselective analysis of the enantiomers of ethotoin in human serum using chiral stationary phase liquid chromatography and gas chromatography-mass spectrometry. Inotsume N, Fujii J, Honda M, Nakano M, Higashi A, Matsuda I.J Chromatogr. 1988 Jul 15;428(2):402-7. No abstract available. PMID: 2905704 </br>6:Rapid and sensitive determination of ethotoin as well as carbamazepine, phenobarbital, phenytoin and primidone in human serum. Inotsume N, Higashi A, Kinoshita E, Matsuoka T, Nakano M.J Chromatogr. 1986 Nov 28;383(1):166-71. No abstract available. PMID: 2880855 </br>7:Ethotoin in seizures of childhood and adolescence. Carter CA, Helms RA, Boehm R.Neurology. 1984 Jun;34(6):791-5. PMID: 6145119 </br>8:Nonlinear ethotoin kinetics. Meyer MC, Holcombe BJ, Burckart GJ, Raghow G, Yau MK.Clin Pharmacol Ther. 1983 Mar;33(3):329-34. PMID: 6130866 </br>9:Ethotoin use in pediatric seizure patients. Korberly BH, Mrazik TJ, Graziani LJ.Am J Dis Child. 1981 Dec;135(12):1139-40. No abstract available. PMID: 6119023 </br>10:Gas chromatographic-mass spectrometric studies on the metabolic fate of ethotoin in man. Bius DL, Yonekawa WD, Kupferberg HJ, Cantor F, Dudley KH.Drug Metab Dispos. 1980 Jul-Aug;8(4):223-9. PMID: 6105055 |
