Ethyl 2-​Ethoxy-​1-​((2'-​(5-​oxo-​2,​5-​dihydro-​1,​2,​4-​oxadiazol-​3-​yl)​-​[1,​1'-​biphenyl]​-​4-​yl)​methyl)​-​1H-​benzo[d]​imidazole-​7-​carboxylate

• CAT Number: C000185
• CAS Number: 1403474-70-3
• Molecular Formula: C₂₇H₂₄N₄O₅
• Molecular Weight: 484.51
• Purity: ≥95%
• Synonyms: Ethyl 1-[[2′-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1′-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate; Azilsartan Kamedoxomil Impurity; Azilsartan Impurity
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Appearance: White to Light Yellow Solid
• Storage: -20°C

Ethyl 2-Ethoxy-1-((2′-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1′-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate(CAT: C000185) is an impurity that can be found in Azilsartan, a pharmaceutical compound used in the treatment of hypertension. This impurity may arise during the synthesis or storage of Azilsartan. It is crucial to monitor and control the levels of this impurity in Azilsartan formulations to ensure the drug’s purity and effectiveness.

Reference

Kohara, Y., et al.: J. Med. Chem., 39, 5228 (1996); Plomgaard, P., et al.: Diabetes, 54, 2939 (2005); Radl, S., et al.: J. Heterocyclic Chem., 50, 929 (2013);