Ethyl 3-Nitrobenzylideneacetoacetate

• CAT Number: C000195
• CAS Number: 39562-16-8
• Molecular Formula: C₁₃H₁₃NO₅
• Molecular Weight: 263.25
• Purity: ≥95%
• Synonyms: Ethyl 2-(3-Nitrobenzylidene)acetoacetate; Ethyl 2-(3′-Nitrobenzylidene)acetoacetate; Ethyl 2-(m-Nitrobenzylidene)acetoacetate; 2-[(3-Nitrophenyl)methylene]-3-oxo-Butanoic Acid Ethyl Ester
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• Appearance: Pale Yellow Solid
• Storage: 20°C

Ethyl 3-Nitrobenzylideneacetoacetate(CAT: C000195) plays a pivotal role in pharmaceutical chemistry, specifically in the synthesis of 5-Ethyl-demethyl Lercanidipine. This compound serves as an impurity in Lercanidipine, a dihydropyridine calcium channel blocker used to treat hypertension. Ethyl 3-Nitrobenzylideneacetoacetate’s involvement as an intermediate underscores its importance in drug synthesis, contributing to the preparation of compounds with specific pharmacological properties.

Reference

Bianchi, G., et al.: Pharmacol. Res., 21, 193 (1989); Rimoldi, E., et al.: Acta Therap., 200, 23 (1994); Argekar, A., et al.: J. Pharm. Biomed. Anal., 21, 1137 (2000);