Ethyl-3,4-dephostatin

For research use only. Not for therapeutic Use.

  • CAT Number: I027085
  • CAS Number: 237756-11-5
  • Molecular Formula: C8H10N2O3
  • Molecular Weight: 182.179
  • Purity: 98%
Inquiry Now

Ethyl-3,4-dephostatin is a novel inhibitor of the interactions of CFTR-associated ligand and PSD-95/Dlg1/ZO-1 domain.


Catalog Number I027085
CAS Number 237756-11-5
Synonyms

Ethyl-3,4-dephostatin; ED;

Molecular Formula C8H10N2O3
Purity 98%
Solubility Soluble in DMSO
Appearance Solid powder
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name N-(3,4-dihydroxyphenyl)-N-ethylnitrous amide
InChI InChI=1S/C8H10N2O3/c1-2-10(9-13)6-3-4-7(11)8(12)5-6/h3-5,11-12H,2H2,1H3
InChIKey ZTXUSFPBLYQDDN-UHFFFAOYSA-N
SMILES O=NN(C1=CC=C(O)C(O)=C1)CC
Reference

1: Zhao Y, Cushing PR, Smithson DC, Pellegrini M, Pletnev AA, Al-Ayyoubi S, Grassetti AV, Gerber SA, Guy RK, Madden DR. Cysteine modifiers suggest an allosteric inhibitory site on the CAL PDZ domain. Biosci Rep. 2018 Jul 6;38(4):BSR20180231. doi: 10.1042/BSR20180231. Erratum in: Biosci Rep. 2018 Jun 5;: PMID: 29472314; PMCID: PMC6435542.
2: Ren JX, Cheng Z, Huang YX, Zhao JF, Guo P, Zou ZM, Xie Y. Identification of novel dual-specificity phosphatase 26 inhibitors by a hybrid virtual screening approach based on pharmacophore and molecular docking. Biomed Pharmacother. 2017 May;89:376-385. doi: 10.1016/j.biopha.2017.02.064. Epub 2017 Feb 27. PMID: 28249240.
3: Seo H, Cho S. Inhibition of dual-specificity phosphatase 26 by ethyl-3,4-dephostatin: Ethyl-3,4-dephostatin as a multiphosphatase inhibitor. Pharmazie. 2016 Apr;71(4):196-200. PMID: 27209699.
4: Akassoglou K. Nerve growth factor-independent neuronal survival: a role for NO donors. Mol Pharmacol. 2005 Oct;68(4):952-5. doi: 10.1124/mol.105.017277. Epub 2005 Jul 26. PMID: 16046659.
5: Culmsee C, Gerling N, Landshamer S, Rickerts B, Duchstein HJ, Umezawa K, Klumpp S, Krieglstein J. Nitric oxide donors induce neurotrophin-like survival signaling and protect neurons against apoptosis. Mol Pharmacol. 2005 Oct;68(4):1006-17. doi: 10.1124/mol.105.013086. Epub 2005 Jul 18. PMID: 16027232.
6: Tomes CN, Roggero CM, De Blas G, Saling PM, Mayorga LS. Requirement of protein tyrosine kinase and phosphatase activities for human sperm exocytosis. Dev Biol. 2004 Jan 15;265(2):399-415. doi: 10.1016/j.ydbio.2003.09.032. PMID: 14732401.

Request a Quote