Ethyl acetate-PEG1

• CAT Number: I044724
• CAS Number: 2093-20-1
• Molecular Formula: C6H12O4
• Molecular Weight: 148.16
• Purity: ≥95%
• Synonyms: 2-(2-hydroxyethoxy)ethyl acetate
• InChI: InChI=1S/C6H12O4/c1-6(8)10-5-4-9-3-2-7/h7H,2-5H2,1H3
• InChIKey: XXXFZKQPYACQLD-UHFFFAOYSA-N
• SMILES: CC(=O)OCCOCCO

Ethyl acetate-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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