For research use only. Not for therapeutic Use.
Ethyl acetate-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I044724 |
| CAS Number | 2093-20-1 |
| Synonyms | 2-(2-hydroxyethoxy)ethyl acetate |
| Molecular Formula | C6H12O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C6H12O4/c1-6(8)10-5-4-9-3-2-7/h7H,2-5H2,1H3 |
| InChIKey | XXXFZKQPYACQLD-UHFFFAOYSA-N |
| SMILES | CC(=O)OCCOCCO |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
