Ethyl-PEG4-alcohol

• CAT Number: I044725
• CAS Number: 5650-20-4
• Molecular Formula: C10H22O5
• Molecular Weight: 222.28
• Purity: ≥95%
• Synonyms: 2-[2-[2-(2-ethoxyethoxy)ethoxy]ethoxy]ethanol
• InChI: InChI=1S/C10H22O5/c1-2-12-5-6-14-9-10-15-8-7-13-4-3-11/h11H,2-10H2,1H3
• InChIKey: GTAKOUPXIUWZIA-UHFFFAOYSA-N
• SMILES: CCOCCOCCOCCOCCO

Ethyl-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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