For research use only. Not for therapeutic Use.
Ethylhydrocupreine hydrochloride（Cat No.:I015200）is a quinoline derivative with notable antibacterial and antimalarial properties. Often used in laboratory and clinical settings, it is effective against gram-positive bacteria and has been applied as an anti-infective agent in ophthalmology, particularly for treating keratitis caused by Haemophilus influenzae. Its mechanism involves disrupting nucleic acid synthesis, which hampers bacterial replication. Ethylhydrocupreine hydrochloride’s activity and stability make it useful for microbiological assays and as a research tool in studying bacterial infections, though its use is mainly limited to specialized applications today.
| Catalog Number | I015200 |
| CAS Number | 3413-58-9 |
| Molecular Formula | C₂₁H₂₉ClN₂O₂ |
| Purity | ≥95% |
| Target | Bacterial |
| IUPAC Name | (R)-(6-ethoxyquinolin-4-yl)-[(2S,4S,5R)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]methanol;hydrochloride |
| InChI | InChI=1S/C21H28N2O2.ClH/c1-3-14-13-23-10-8-15(14)11-20(23)21(24)17-7-9-22-19-6-5-16(25-4-2)12-18(17)19;/h5-7,9,12,14-15,20-21,24H,3-4,8,10-11,13H2,1-2H3;1H/t14-,15-,20-,21+;/m0./s1 |
| InChIKey | QNRATNLHPGXHMA-XZHTYLCXSA-N |
| SMILES | CC[C@H]1CN2CC[C@H]1C[C@H]2[C@@H](C3=C4C=C(C=CC4=NC=C3)OCC)O.Cl |
| Reference | [1]. J A Kolmer, et al. CHEMOTHERAPEUTIC STUDIES WITH ETHYLHYDROCUPREINE HYDROCHLORIDE IN EXPERIMENTAL PNEUMOCOCCUS PLEURITIS. J Exp Med. 1921 May 31;33(6):693-711.<br>[2]. Paulo R Cortes, et al. Subinhibitory Concentrations of Penicillin Increase the Mutation Rate to Optochin Resistance in Streptococcus Pneumoniae. J Antimicrob Chemother. 2008 Nov;62(5):973-7.<br>[3]. Nassira Mahmoudi, et al. Identification of New Antimalarial Drugs by Linear Discriminant Analysis and Topological Virtual Screening. J Antimicrob Chemother. 2006 Mar;57(3):489-97.<br>[4]. Antonella Di Pizio, et al. Molecular Features Underlying Selectivity in Chicken Bitter Taste Receptors. Front Mol Biosci. 2018 Jan 31;5:6. |
