Etidronate

  • CAT Number: A000482
  • CAS Number: 2809-21-4
  • Molecular Formula: C2H8O7P2
  • Molecular Weight: 206.03
  • Purity: ≥95%
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Etidronate (CAT: A000482) is a non-aminobisphosphonate compound with versatile pharmacological properties. It exhibits protein tyrosine phosphatase (PTP) inhibitory activity, making it valuable for treating Paget’s disease and preventing heterotopic ossification. The mechanism of action includes direct inhibition of osteoclastic bone-resorbing activity, induction of apoptosis, and disruption of actin rings in osteoclasts. In experimental studies, Etidronate has demonstrated efficacy in suppressing mechanical allodynia and preserving bone mineral density in arthritic animal models. Its multifaceted activities contribute to its relevance in pharmaceutical and medical research, particularly in bone health and pain management studies.


Catalog Number A000482
CAS Number 2809-21-4
Synonyms

NA

Molecular Formula C2H8O7P2
Purity ≥95%
Target protein tyrosine phosphatase
Storage 3 years -20C powder
Overview of Clinical Research

<span style=”color:#000000;”><span style=”font-family:arial,helvetica,sans-serif;”><span style=”font-size:12px;”>Etidronate is a bone resorption factor inhibitor and a DNA synthesis inhibitor.&nbsp;<span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>The phase I trial in Bone metastases in Russia (IV) (NCT02673060) is ongoing.</span></span></span></span>

IUPAC Name (1-hydroxy-1-phosphonoethyl)phosphonic acid
InChI InChI=1S/C2H8O7P2/c1-2(3,10(4,5)6)11(7,8)9/h3H,1H3,(H2,4,5,6)(H2,7,8,9)
InChIKey DBVJJBKOTRCVKF-UHFFFAOYSA-N
SMILES CC(O)(P(=O)(O)O)P(=O)(O)O
Reference

<span style=”color:#000000;”><span style=”font-family:arial,helvetica,sans-serif;”><span style=”font-size:12px;”>1.<span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>Hiroi-Furuya, E., et al. &quot;Etidronate (EHDP) inhibits osteoclastic-bone resorption, promotes apoptosis and disrupts actin rings in isolate-mature osteoclasts.&quot;&nbsp;</span><i style=”font-family: Arial, sans-serif; font-size: 13px; font-variant-ligatures: normal; orphans: 2; widows: 2;”>Calcified tissue international</i><span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>&nbsp;64.3 (1999): 219-223.<br />
2.</span><span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>Kawabata, Atsufumi, et al. &quot;Antiallodynic effect of etidronate, a bisphosphonate, in rats with adjuvant-induced arthritis: involvement of ATP-sensitive K+ channels.&quot;&nbsp;</span><i style=”font-family: Arial, sans-serif; font-size: 13px; font-variant-ligatures: normal; orphans: 2; widows: 2;”>Neuropharmacology</i><span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>&nbsp;51.2 (2006): 182-190.<br />
3.</span><span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>Funayama, H., et al. &quot;Inhibition of inflammatory and bone-resorption&ndash;inhibitory effects of alendronate by etidronate.&quot;&nbsp;</span><i style=”font-family: Arial, sans-serif; font-size: 13px; font-variant-ligatures: normal; orphans: 2; widows: 2;”>Calcified tissue international</i><span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>&nbsp;76.6 (2005): 448-457.<br />
4.</span><span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>Tamura, Kazuhiro, et al. &quot;Effect of etidronate on aortic calcification and bone metabolism in calcitoriol-treated rats with subtotal nephrectomy.&quot;&nbsp;</span><i style=”font-family: Arial, sans-serif; font-size: 13px; font-variant-ligatures: normal; orphans: 2; widows: 2;”>Journal of pharmacological sciences</i><span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>&nbsp;99.1 (2005): 89-94.<br />
5.</span><span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>Tamura, Kazuhiro, et al. &quot;Prevention of aortic calcification by etidronate in the renal failure rat model.&quot;&nbsp;</span><i style=”font-family: Arial, sans-serif; font-size: 13px; font-variant-ligatures: normal; orphans: 2; widows: 2;”>European journal of pharmacology</i><span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>&nbsp;558.1-3 (2007): 159-166.</span></span></span></span>

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