For research use only. Not for therapeutic Use.
Etofenprox is an orally active non-ester pyrethroid insecticide. Etofenprox induces toxicity against many pest insects, including Diptera rather than mammalian and fish. Etofenprox has a liver tumor-promoting activity in rats accompanied with microsomal ROS production increase. Etofenprox can be used in agricultural pest control and malaria research[1][2].
Etofenprox induces toxicity in the housefly M. domestica with LD50 of 23 ng/fly)[1].
Etofenprox (powder; 0.25, 0.5, and 1%; p.o.; daily for 8 wk) shows a promotion on liver tumor in male F344 rats, indicating the activation of constitutive active/androstane receptor (CAR) and enhances microsomal ROS production, resulting in the up-regulation of Nrf2 gene batteries[2].
| Catalog Number | R026447 |
| CAS Number | 80844-07-1 |
| Synonyms | 1-ethoxy-4-[2-methyl-1-[(3-phenoxyphenyl)methoxy]propan-2-yl]benzene |
| Molecular Formula | C25H28O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C25H28O3/c1-4-27-22-15-13-21(14-16-22)25(2,3)19-26-18-20-9-8-12-24(17-20)28-23-10-6-5-7-11-23/h5-17H,4,18-19H2,1-3H3 |
| InChIKey | YREQHYQNNWYQCJ-UHFFFAOYSA-N |
| SMILES | CCOC1=CC=C(C=C1)C(C)(C)COCC2=CC(=CC=C2)OC3=CC=CC=C3 |
| Reference | [1]. Hemingway J. Efficacy of etofenprox against insecticide susceptible and resistant mosquito strains containing characterized resistance mechanisms. Med Vet Entomol. 1995 Oct;9(4):423-6. [2]. Hojo Y, et al. Liver tumor promoting effect of etofenprox in rats and its possible mechanism of action. J Toxicol Sci. 2012;37(2):297-306. |
