Etomidate hydrochloride

• CAT Number: I003948
• CAS Number: 53188-20-8
• Molecular Formula: C14H17ClN2O2
• Molecular Weight: 280.75
• Purity: ≥95%
• Synonyms: ethyl 3-[(1S)-1-phenylethyl]imidazole-4-carboxylate;hydrochloride
• Target: GABA Receptor
• Solubility: DMSO 50 mg/Ml; Water <1 mg/Ml; Ethanol 50 mg/mL
• Storage: Store at -20C
• IUPAC Name: ethyl 3-[(1R)-1-phenylethyl]imidazole-4-carboxylate;hydrochloride
• InChI: InChI=1S/C14H16N2O2.ClH/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12;/h4-11H,3H2,1-2H3;1H/t11-;/m1./s1
• InChIKey: NCDXBSVHIGDPOE-RFVHGSKJSA-N
• SMILES: CCOC(=O)C1=CN=CN1[C@H](C)C2=CC=CC=C2.Cl

Etomidate hydrochloride（Cat No.:I003948）is an intravenous anesthetic agent used for the induction of general anesthesia and sedation. It acts by enhancing the effects of the neurotransmitter gamma-aminobutyric acid (GABA) at GABA-A receptors in the brain, leading to central nervous system depression and unconsciousness. Etomidate is particularly favored for its rapid onset and short duration of action, making it suitable for brief procedures. It is often used in emergency settings for intubation and in patients with hemodynamic instability because it has minimal cardiovascular effects. Common side effects include pain at the injection site, nausea, and adrenal suppression with prolonged use.

Reference

[1]. Mehta, M.P., et al., Etomidate anesthesia inhibits the cortisol response to surgical stress. Acta Anaesthesiol Scand, 1985. 29(5): p. 486-9.

[2]. Griesdale, D.E., Etomidate for intubation of patients who have sepsis or septic shock – where do we go from here? Crit Care, 2012. 16(6): p. 189.

[3]. Cherfan, A.J., et al., Etomidate and mortality in cirrhotic patients with septic shock. BMC Clin Pharmacol, 2011. 11: p. 22.