For research use only. Not for therapeutic Use.
Etozolin (Cat No.: I006735) is a diuretic drug belonging to the thiazide-like class, primarily used to treat hypertension and edema associated with heart failure and kidney disease. It works by inhibiting sodium and chloride reabsorption in the renal tubules, promoting fluid excretion and reducing blood pressure. Etozolin has a longer duration of action compared to traditional thiazides, making it effective for sustained diuresis. Its balanced efficacy and tolerability make it a valuable option for managing fluid retention and hypertension-related complications.
| CAS Number | 73-09-6 |
| Synonyms | Etozolin; W-2900A; W 2900A; W2900A; GO 687; GO-687; GO687; Diulozin; Elkapin;ethyl (E)-2-(3-methyl-4-oxo-5-(piperidin-1-yl)thiazolidin-2-ylidene)acetate |
| Molecular Formula | C13H20N2O3S |
| Purity | ≥95% |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4°C for short term or -20 °C for long term |
| IUPAC Name | ethyl (2E)-2-(3-methyl-4-oxo-5-piperidin-1-yl-1,3-thiazolidin-2-ylidene)acetate |
| InChI | 1S/C13H20N2O3S/c1-3-18-11(16)9-10-14(2)12(17)13(19-10)15-7-5-4-6-8-15/h9,13H,3-8H2,1-2H3/b10-9+ |
| InChIKey | ZCKKHYXUQFTBIK-MDZDMXLPSA-N |
| SMILES | CCOC(=O)/C=C/1\N(C(=O)C(S1)N2CCCCC2)C |
| Reference | </br>1:Acute antihypertensive, diuretic and metabolic effects of etozolin and chlorthalidone. Nami R, Lucani B, Pavese G, Panza F, Moscato D, Martinelli M, Gennari C.Panminerva Med. 1991 Jul-Sep;33(3):157-63. PMID: 1771100 </br>2:[Arterial hypertension in perimenopausal women; tolerability of etozolin]. Cellina G, Binaghi P, De Carolis ME, Limonta A, Lo Cicero G, Di Michele R.Minerva Cardioangiol. 1990 Jul-Aug;38(7-8):341-4. Italian. PMID: 2080024 </br>3:[Etozolin and captopril in the treatment of arterial hypertension]. Battaglia A, Adamo M, Di Stefano G, Gargano F.Clin Ter. 1990 Feb 15;132(3):173-9. Italian. PMID: 2139827 </br>4:Etozolin monotherapy and combination with verapamil in essential hypertension. Muiesan G, Agabiti-Rosei E.J Hypertens Suppl. 1989 Dec;7(6):S278-9. PMID: 2698939 </br>5:[Etozolin in the treatment of essential arterial hypertension of mild-to-moderate degree]. Salerno L, Pepe S, Salli L, Curiale B, Agnello C, Ferraro A.Minerva Cardioangiol. 1988 Jan-Feb;36(1-2):43-8. Italian. No abstract available. PMID: 3386853 </br>6:Altered kinetics of etozolin and its active metabolite ozolinone in hepatitis and hepatic cirrhosis with ascites. Knauf H, Missmahl M, Schölmerich J, Gerok W, Mutschler E.Arzneimittelforschung. 1987 Dec;37(12):1385-8. PMID: 3449068 </br>7:[Experience with etozolin, a new diuretic]. Vrzánová M, Osten J, Horácková M.Vnitr Lek. 1986 Feb;32(2):190-4. Czech. No abstract available. PMID: 3962200 </br>8:Pharmacodynamics and kinetics of etozolin/ozolinone in hypertensive patients with normal and impaired kidney function. Knauf H, Liebig R, Schollmeyer P, Rosenthal J, Kölle EU, Mutschler E.Eur J Clin Pharmacol. 1984;26(6):687-93. PMID: 6386484 </br>9:Placental transfer of etozolin and ozolinone during the first half of gestation in man. Nau H, Steldinger R, Ivan E.Eur J Clin Pharmacol. 1982;23(3):253-60. PMID: 7173295 </br>10:Determination of etozolin and ozolinone in human plasma and tissues by reversed-phase high-performance liquid chromatography. Liddiard C, Nau H.J Chromatogr. 1981 Oct 9;225(2):504-8. No abstract available. PMID: 7298786 |
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