ETP-47799

• CAT Number: I024279
• CAS Number: 923596-52-5
• Molecular Formula: C14H15N5
• Molecular Weight: 253.3
• Purity: ≥95%
• IUPAC Name: N-propyl-3-pyridin-4-ylimidazo[1,2-b]pyridazin-6-amine
• InChI: InChI=1S/C14H15N5/c1-2-7-16-13-3-4-14-17-10-12(19(14)18-13)11-5-8-15-9-6-11/h3-6,8-10H,2,7H2,1H3,(H,16,18)
• SMILES: CCCNC1=NN2C(=NC=C2C3=CC=NC=C3)C=C1

ETP-47799 is a potent CDK8/19 inhibitor with IC50 values of 2.9 nM and 14.1 nM for CDK8 and CDK19, respectively. ETP-47799 stimulates Mediator recruitment of RNA Pol II. This effectively hyper-activates enhancers and stabilizes the transcriptional program of naïve pluripotent cell identity.
Keywords: ETP-47799 | Supplier | CDK8/CDK19 inhibitor | CDK8/19i | ETP47799 | ETP 47799 | CAS [923596-52-5] | DNA-RNA | CDK | Inhibitor | Enzymes | Pluripotent stem cells | PSC

Reference

CJ Lynch et al. Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases. Nat Cell Biol. 2020 Oct;22(10):1223-1238.