For research use only. Not for therapeutic Use.
Etrasimod (Cat No.: I006736) is a selective sphingosine-1-phosphate receptor modulator (S1P1, S1P4, S1P5) developed for autoimmune and inflammatory diseases. It regulates lymphocyte trafficking, reducing immune cell migration to inflamed tissues. Etrasimod is being investigated for ulcerative colitis, Crohn’s disease, atopic dermatitis, and other immune-mediated conditions. With a favorable safety profile and once-daily oral dosing, it offers advantages over existing S1P modulators. Its targeted mechanism helps balance immune response while minimizing systemic immunosuppression, making it a promising therapy for chronic inflammatory diseases.
| CAS Number | 1206123-37-6 |
| Synonyms | APD334; APD-334; APD 334; Etrasimod.;(R)-2-(7-((4-cyclopentyl-3-(trifluoromethyl)benzyl)oxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid |
| Molecular Formula | C26H26F3NO3 |
| Purity | ≥95% |
| Target | LPL Receptor |
| Solubility | Soluble in DMSO, not in water |
| Storage | Store at -20°C |
| InChI | InChI=1S/C26H26F3NO3/c27-26(28,29)22-11-15(5-8-19(22)16-3-1-2-4-16)14-33-18-7-10-23-21(13-18)20-9-6-17(12-24(31)32)25(20)30-23/h5,7-8,10-11,13,16-17,30H,1-4,6,9,12,14H2,(H,31,32)/t17-/m1/s1 |
| InChIKey | MVGWUTBTXDYMND-QGZVFWFLSA-N |
| SMILES | OC(C[C@H]1CCC2=C1NC3=CC=C(OCC4=CC=C(C5CCCC5)C(C(F)(F)F)=C4)C=C32)=O |
| Reference | </br>1: Buzard DJ, Kim SH, Lopez L, Kawasaki A, Zhu X, Moody J, Thoresen L, Calderon I, Ullman B, Han S, Lehmann J, Gharbaoui T, Sengupta D, Calvano L, Montalban AG, Ma YA, Sage C, Gao Y, Semple G, Edwards J, Barden J, Morgan M, Chen W, Usmani K, Chen C, Sadeque A, Christopher RJ, Thatte J, Fu L, Solomon M, Mills D, Whelan K, Al-Shamma H, Gatlin J, Le M, Gaidarov I, Anthony T, Unett DJ, Blackburn A, Rueter J, Stirn S, Behan DP, Jones RM. Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate-1 Receptor. ACS Med Chem Lett. 2014 Nov 4;5(12):1313-7. doi: 10.1021/ml500389m. eCollection 2014 Dec 11. PubMed PMID: 25516790; PubMed Central PMCID: PMC4265817. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
