Evodiamine

• CAT Number: I003873
• CAS Number: 518-17-2
• Molecular Formula: C19H17N3O
• Molecular Weight: 303.4
• Purity: ≥95%
• Synonyms: D-Evodiamine
• Solubility: DMSO
• Storage: 3 years -20C powder
• InChIKey: TXDUTHBFYKGSAH-SFHVURJKSA-N

Evodiamine (CAT: I003873) is a natural compound derived from the plant Evodia rutaecarpa. It has been studied for its various pharmacological properties, including anti-inflammatory, anticancer, and thermogenic effects. Evodiamine is believed to exert its biological effects through multiple mechanisms, such as activating transient receptor potential vanilloid subtype 1 (TRPV1) channels, inhibiting cell proliferation, inducing apoptosis, and modulating various signaling pathways. It has also been investigated for its potential in weight loss and metabolic regulation. Evodiamine shows promise as a natural compound with diverse therapeutic applications, but further research is needed to fully understand its mechanisms of action and clinical potential.

Reference

[1]. Wang S, et al. Scaffold Diversity Inspired by the Natural Product Evodiamine: Discovery of Highly Potent and Multitargeting Antitumor Agents. J Med Chem. 2015 Aug 27;58(16):6678-96.

[2]. Li RF,et al. Effects of Evodiamine on the Pharmacokinetics of Dapoxetine and Its Metabolite Desmethyl Dapoxetine inRats. Pharmacology. 2016;97(1-2):43-7.

[3]. Shi L, et al. Evodiamine exerts anti-tumor effects against hepatocellular carcinoma through inhibiting β-catenin-mediated angiogenesis. Tumour Biol. 2016 Sep;37(9):12791-12803.